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(1-(4-Nitrophenyl)piperidin-3-yl)Methanol

Product Name
(1-(4-Nitrophenyl)piperidin-3-yl)Methanol
CAS No.
166438-83-1
Chemical Name
(1-(4-Nitrophenyl)piperidin-3-yl)Methanol
Synonyms
piperidin-3-yl);3-Piperidinemethanol, 1-(4-nitrophenyl)-;(1-(4-Nitrophenyl)piperidin-3-yl)Methanol
CBNumber
CB92549775
Molecular Formula
C12H16N2O3
Formula Weight
236.27
MOL File
166438-83-1.mol
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(1-(4-Nitrophenyl)piperidin-3-yl)Methanol Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific
Product number
074766
Product name
(1-(4-Nitrophenyl)piperidin-3-yl)methanol
Purity
95+%
Packaging
1g
Price
$416
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167391
Product name
(1-(4-NITROPHENYL)PIPERIDIN-3-YL)METHANOL
Purity
95.00%
Packaging
1G
Price
$1034.88
Updated
2021/12/16
Matrix Scientific
Product number
074766
Product name
(1-(4-Nitrophenyl)piperidin-3-yl)methanol
Purity
95+%
Packaging
5g
Price
$1197
Updated
2021/12/16
AK Scientific
Product number
W3619
Product name
(1-(4-Nitrophenyl)piperidin-3-yl)methanol
Packaging
250mg
Price
$124
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167391
Product name
(1-(4-NITROPHENYL)PIPERIDIN-3-YL)METHANOL
Purity
95.00%
Packaging
5G
Price
$2067.45
Updated
2021/12/16
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(1-(4-Nitrophenyl)piperidin-3-yl)Methanol Chemical Properties,Usage,Production

Synthesis

4606-65-9

350-46-9

166438-83-1

General procedure for the synthesis of (1-(4-nitrophenyl)piperidin-3-yl)methanol from 3-hydroxymethylpiperidine and p-fluoronitrobenzene: A mixture of piperidin-3-ylmethanol (2.0 g, 1.0 eq.) with 1-fluoro-4-nitrobenzene (2.94 g, 1.2 eq.) in DMSO (20 mL) was placed in an airtight vial with stirring and the reaction system heated up to 100 °C. The reaction process was monitored by thin layer chromatography (TLC) for 12 hours. Upon completion of the reaction, the reaction mixture was quenched with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to afford (1-(4-nitrophenyl)piperidin-3-yl)methanol as a yellow solid (3.0 g, 75% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.08 (d, 1H), 6.805 (d, 1H), 3.98 (m, 1H), 3.81 (d, 1H), 3.64 (m, 1H), 3.53 (m, 1H), 3.041 (m, 1H), 2.878 (m, 1H), 1.838 (m. 3H), 1.621 (m, 2H), 1.294 (d, 1H).

References

[1] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 100

(1-(4-Nitrophenyl)piperidin-3-yl)Methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(1-(4-Nitrophenyl)piperidin-3-yl)Methanol Suppliers

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166438-83-1, (1-(4-Nitrophenyl)piperidin-3-yl)MethanolRelated Search:


  • (1-(4-Nitrophenyl)piperidin-3-yl)Methanol
  • piperidin-3-yl)
  • 3-Piperidinemethanol, 1-(4-nitrophenyl)-
  • 166438-83-1