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CAY10502

Product Name
CAY10502
CAS No.
888320-29-4
Chemical Name
CAY10502
Synonyms
CAY10502;CAY10502,CAY-10502;CAY10502 Exclusive;NXDZVUAKVFVDSL-UHFFFAOYSA-N;1H-Indole-3,5-dicarboxylic acid, 1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-, 3-methyl ester
CBNumber
CB92590414
Molecular Formula
C30H37NO7
Formula Weight
523.62
MOL File
888320-29-4.mol
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CAY10502 Property

Boiling point:
693.6±55.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form 
A crystalline solid
pka
4.05±0.30(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10008657
Product name
CAY10502
Purity
≥98% (mixture of isomers)
Packaging
500μg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
10008657
Product name
CAY10502
Purity
≥98% (mixture of isomers)
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10008657
Product name
CAY10502
Purity
≥98% (mixture of isomers)
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
10008657
Product name
CAY10502
Purity
≥98% (mixture of isomers)
Packaging
10mg
Price
$409
Updated
2022/04/27
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CAY10502 Chemical Properties,Usage,Production

Description

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.1 CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets.2 It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.2

Uses

CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases[1][2][3].

in vivo

CAY10502-injected (2.5, 25, 100 nM; 5 μL) eyes demonstrates a dose-dependent inhibition of retinal neovascularization (NV) in rat oxygen-induced retinopathy (OIR)[2].

Animal Model:OIR and room air (RA) Sprague-Dawley rat[2]
Dosage:2.5, 25, 100 nM; 5 μL
Administration:Intravitreal Injection
Result:Injection of 100 nM CAY10502 resulted in a 53.1% reduction in NV compared with vehicle treatment.

IC 50

cPLA2α: 4.3 nM (IC50)

References

1. Schaloske, R.H., and Dennis, E.A. The phospholipase A2 superfamily and its group numbering system Biochim. Biophys. Acta 1761,1246-1259(2006).
2. Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α J. Med. Chem. 49,2611-2620(2006).

CAY10502 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10502 Suppliers

China 28 United States 5 Global 33
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 13167063860
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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010-50973130 18101056239
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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RD International Technology Co., Limited
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Cayman Chemical Company
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sales@caymanchem.com
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Santa Cruz Biotechnology Inc
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021-60936350
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Neobioscience Co., Ltd.
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Absin Bioscience Inc.
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Xiamen Huijia Biological Technology Co., Ltd.
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Beijing Shengke Boyuan Biotechnology Co., Ltd.
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888320-29-4, CAY10502Related Search:


  • NXDZVUAKVFVDSL-UHFFFAOYSA-N
  • CAY10502 Exclusive
  • CAY10502
  • CAY10502,CAY-10502
  • 1H-Indole-3,5-dicarboxylic acid, 1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-, 3-methyl ester
  • 888320-29-4