ChemicalBook > CAS DataBase List > 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
- Product Name
- 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
- CAS No.
- 193356-17-1
- Chemical Name
- 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
- Synonyms
- 184833;Co 101244 HCl;1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-;Co 101244 hydrochloride (also known as PD 174494 and Ro 63-1908);1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride;4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride;Inhibitor,Co 101244,Co-101244,Co 101244 hydrochloride,Ionotropic glutamate receptors,inhibit,NR2B,Co101244,PD174494,iGluR,PD 174494,neuroprotective,PD-174494,NMDA
- CBNumber
- CB92639337
- Molecular Formula
- C21H28ClNO3
- Formula Weight
- 377.90492
- MOL File
- 193356-17-1.mol
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4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Property
- Melting point:
- 133-135 °C
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in water and to 50 mM in DMSO
- form
- Powder
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
TRC
- Product number
- C781033
- Product name
- Co101244Hydrochloride
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
TRC
- Product number
- C781033
- Product name
- Co101244Hydrochloride
- Packaging
- 2.5mg
- Price
- $220
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7062
- Product name
- Co101244hydrochloride
- Packaging
- 10mg
- Price
- $294
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7062
- Product name
- Co101244hydrochloride
- Packaging
- 50mg
- Price
- $1246
- Updated
- 2021/12/16
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4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Chemical Properties,Usage,Production
Description
Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effectsin vivoandin vitro.
Uses
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].
in vivo
Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].
storage
Store at +4°C
References
[1] Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. DOI:10.1073/pnas.0903546106
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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