tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate

Product Name: tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
CAS No.: 1032903-63-1
Chemical Name: tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
Synonyms: 4-(1-Boc-4-piperidyl)-2-isopropoxy-5-methylaniline;N-Boc-4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine;tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine...;tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate;TERT-BUTYL 4-(4-AMINO-5-ISOPROPOXY-2-METHYLPHENYLI，I FE)PIPERIDINE-1-CARBOXYLATE;4-(4-AMino-5-isopropoxy-2-Methyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-[4-amino-2-methyl-5-(1-methylethoxy)phenyl]-, 1,1-dimethylethyl ester
CBNumber: CB92663798
Molecular Formula: C20H32N2O3
Formula Weight: 348.48
MOL File: 1032903-63-1.mol

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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Property

Boiling point:: 470.4±45.0 °C(Predicted)
Density: 1.072±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.16±0.16(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B811213
Product name: tert-Butyl4-(4-Amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
Packaging: 50mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 4109AH
Product name: tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
Packaging: 10g
Price: $571
Updated: 2021/12/16

Ambeed

Product number: A138834
Product name: tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Ambeed

Product number: A138834
Product name: tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $61
Updated: 2021/12/16

Ambeed

Product number: A138834
Product name: tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 5g
Price: $182
Updated: 2021/12/16

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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

1032903-52-8

1032903-63-1

Tert-butyl 4-(5-isopropyl-2-methyl-4-nitrophenyl)-3,6-dihydropyridine-1-carboxylate (22.6 g, 0.06 mol) was used as a raw material, which was added to methanol (226 mL) with carbon-loaded palladium hydroxide (20% w/w, 2.26 g). The reaction mixture was stirred at 30-40 °C for 5 h in hydrogen pressure (1 MPa). The completion of the reaction was monitored by TLC. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. To the concentrate n-heptane was added and stirred at 0-10 °C for 2 h to crystallize. The crystals were collected by filtration and the filter cake was dried under vacuum at 40-50 °C to afford tert-butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate as a white solid powder (19.9 g, yield: 95.0%).

References

[1] Patent: CN105461616, 2016, A. Location in patent: Paragraph 0031; 0032; 0033
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0164; 0167
[3] Patent: KR2016/147358, 2016, A. Location in patent: Paragraph 0238-0240
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3738 - 3743
[5] Patent: CN108276410, 2018, A. Location in patent: Paragraph 0129; 0130; 0131

tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Suppliers

China 76 India 1 United Kingdom 1 United States 1 Global 79

A.J Chemicals

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View Lastest Price from tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate 1032903-63-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-30

1032903-63-1, tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylateRelated Search:

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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate

4-(4-AMino-5-isopropoxy-2-Methyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

1-Piperidinecarboxylic acid, 4-[4-amino-2-methyl-5-(1-methylethoxy)phenyl]-, 1,1-dimethylethyl ester

TERT-BUTYL 4-(4-AMINO-5-ISOPROPOXY-2-METHYLPHENYLI，I FE)PIPERIDINE-1-CARBOXYLATE

tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine...

4-(1-Boc-4-piperidyl)-2-isopropoxy-5-methylaniline

N-Boc-4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine

1032903-63-1

1032603-63-1