Kalydeco hydrate

Product Name: Kalydeco hydrate
CAS No.: 1134822-07-3
Chemical Name: Kalydeco hydrate
Synonyms: VX770 hydrate;VX-770 hydrate;VX 770 hydrate;Kalydeco hydrate;Ivacaftor (hydrate);Ivacaftor hydrate (VX-770);Ivacaftor hydrate (VX-770 hydrate;(Z)-N-(2,4-DI-TERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBIMIDIC ACID HYDRATE
CBNumber: CB92666643
Molecular Formula: C24H30N2O4
Formula Weight: 410.51
MOL File: 1134822-07-3.mol

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Kalydeco hydrate Property

storage temp.: Store at -20°C
solubility: 25℃: DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3511
Product name: Ivacaftorhydrate
Packaging: 10mg
Price: $119
Updated: 2021/12/16

ApexBio Technology

Product number: A3511
Product name: Ivacaftorhydrate
Packaging: 50mg
Price: $154
Updated: 2021/12/16

ApexBio Technology

Product number: A3511
Product name: Ivacaftorhydrate
Packaging: 100mg
Price: $213
Updated: 2021/12/16

ApexBio Technology

Product number: A3511
Product name: Ivacaftorhydrate
Packaging: 5mg
Price: $79
Updated: 2021/12/16

Crysdot

Product number: CD31004506
Product name: Ivacaftorhydrate
Purity: 98+%
Packaging: 10mg
Price: $94
Updated: 2021/12/16

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Kalydeco hydrate Chemical Properties,Usage,Production

Description

Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.

Uses

Ivacaftor hydrate (VX-770 hydrate) is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.

in vitro

In Vitro:Ivacaftor (10?μM) increases the PC secretion activity by 3-fold for ABCB4-G535D, 13.7-fold for ABCB4-G536R, 6.7-fold for ABCB4-S1076C, 9.4-fold for ABCB4-S1176L, and 5.7-fold for ABCB4-G1178S. Ivacaftor corrects the functional defect of ABCB4 mutants[1]. Ivacaftor (10 μM) significantly increases CFTR activity in W1282X-expressing cells compared to R1162X CFTR cells[2]. Ivacaftor shows no significant activity against 160 targets tested including the GABAA benzodiazepine receptor. Ivacaftor increases the chloride secretion with an EC50 of 0.236 ± 0.200 μM, a 10-fold shift in potency compared to the F508del HBEs[3]. In recombinant cells, VX-770 increases CFTR channel open probability (Po) in both the F508del processing mutation and the G551D gating mutation. VX-770 increases forskolin-stimulated IT in temperature-corrected F508del-FRT cells by appr 6-fold with an EC50 of 25 nM[4].

in vivo

In Vivo:Ivacaftor (1-200 mg/kg, p.o.) exhibits good oral bioavailability in rat[3].

References

References:[1]. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570. [2]. Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29. [3]. Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-95 [4]. Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.

Kalydeco hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Kalydeco hydrate Suppliers

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View Lastest Price from Kalydeco hydrate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ivacaftor hydrate 1134822-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ivacaftor hydrate 1134822-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1134822-07-3, Kalydeco hydrateRelated Search:

Ivacaftor (hydrate)

Kalydeco hydrate

VX 770 hydrate

VX770 hydrate

Ivacaftor hydrate (VX-770 hydrate

VX-770 hydrate

(Z)-N-(2,4-DI-TERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBIMIDIC ACID HYDRATE

Ivacaftor hydrate (VX-770)

1134822-07-3