ChemicalBook > CAS DataBase List > Indotecan

Indotecan

Product Name
Indotecan
CAS No.
915303-09-2
Chemical Name
Indotecan
Synonyms
LMP-400);Indotecan;NSC-724998;Indotecan (LMP400);FMFIFGLHVOZDEL-UHFFFAOYSA-N;LMP400; LMP-400; LMP 400; INDOTECAN;LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-
CBNumber
CB92668485
Molecular Formula
C26H26N2O7
Formula Weight
478.49
MOL File
915303-09-2.mol
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Indotecan Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to gray
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0007476
Product name
Indotecan
Purity
>98.0%
Packaging
5mg
Price
$205
Updated
2021/12/16
ChemScene
Product number
CS-0007476
Product name
Indotecan
Purity
>98.0%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0007476
Product name
Indotecan
Purity
>98.0%
Packaging
50mg
Price
$1050
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573435
Product name
Indotecan(LMP400)
Purity
>98%
Packaging
100mg
Price
$1654.1
Updated
2021/12/16
ChemScene
Product number
CS-0007476
Product name
Indotecan
Purity
>98.0%
Packaging
100mg
Price
$1850
Updated
2021/12/16
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Indotecan Chemical Properties,Usage,Production

Uses

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].

in vivo

Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice[2].

Animal Model:Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein[2]
Dosage:2.5 mg/kg body weight per injection
Administration:Intraperitoneally every 2 days for 15 days (total, eight doses)
Result:A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.

IC 50

Topoisomerase I

References

[1] Bala?a-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454

Indotecan Preparation Products And Raw materials

Raw materials

Preparation Products

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Indotecan Suppliers

CHINA 26 United States 3 Global 29
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Suzhou Ran enzyme Biotechnology Co., Ltd.
Tel
0512-0512-62793604 18015430729
Fax
0512-62793604
Email
116667374@qq.com
Country
China
ProdList
127
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
9974
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58

915303-09-2, IndotecanRelated Search:


  • Indotecan
  • Indotecan (LMP400)
  • FMFIFGLHVOZDEL-UHFFFAOYSA-N
  • LMP-400)
  • LMP400; LMP-400; LMP 400; INDOTECAN
  • NSC-724998
  • 5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-
  • LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400
  • 2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
  • 2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
  • 915303-09-2