Indotecan

Product Name: Indotecan
CAS No.: 915303-09-2
Chemical Name: Indotecan
Synonyms: LMP-400);Indotecan;NSC-724998;Indotecan (LMP400);FMFIFGLHVOZDEL-UHFFFAOYSA-N;LMP400; LMP-400; LMP 400; INDOTECAN;LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-
CBNumber: CB92668485
Molecular Formula: C26H26N2O7
Formula Weight: 478.49
MOL File: 915303-09-2.mol

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Indotecan Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0007476
Product name: Indotecan
Purity: >98.0%
Packaging: 5mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-0007476
Product name: Indotecan
Purity: >98.0%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0007476
Product name: Indotecan
Purity: >98.0%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573435
Product name: Indotecan(LMP400)
Purity: >98%
Packaging: 100mg
Price: $1654.1
Updated: 2021/12/16

ChemScene

Product number: CS-0007476
Product name: Indotecan
Purity: >98.0%
Packaging: 100mg
Price: $1850
Updated: 2021/12/16

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Indotecan Chemical Properties,Usage,Production

Uses

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].

in vivo

Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice^[2].

Animal Model:	Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein^[2]
Dosage:	2.5 mg/kg body weight per injection
Administration:	Intraperitoneally every 2 days for 15 days (total, eight doses)
Result:	A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.

IC 50

Topoisomerase I

References

[1] Bala?a-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454

Indotecan Preparation Products And Raw materials

Raw materials

Preparation Products

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Indotecan Suppliers

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915303-09-2, IndotecanRelated Search:

Indotecan

Indotecan (LMP400)

FMFIFGLHVOZDEL-UHFFFAOYSA-N

LMP-400)

LMP400; LMP-400; LMP 400; INDOTECAN

NSC-724998

5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-

LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400

2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

915303-09-2