Indotecan
- Product Name
- Indotecan
- CAS No.
- 915303-09-2
- Chemical Name
- Indotecan
- Synonyms
- LMP-400);Indotecan;NSC-724998;Indotecan (LMP400);FMFIFGLHVOZDEL-UHFFFAOYSA-N;LMP400; LMP-400; LMP 400; INDOTECAN;LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-
- CBNumber
- CB92668485
- Molecular Formula
- C26H26N2O7
- Formula Weight
- 478.49
- MOL File
- 915303-09-2.mol
Indotecan Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to gray
N-Bromosuccinimide Price
- Product number
- CS-0007476
- Product name
- Indotecan
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CS-0007476
- Product name
- Indotecan
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0007476
- Product name
- Indotecan
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- orb573435
- Product name
- Indotecan(LMP400)
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1654.1
- Updated
- 2021/12/16
- Product number
- CS-0007476
- Product name
- Indotecan
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $1850
- Updated
- 2021/12/16
Indotecan Chemical Properties,Usage,Production
Uses
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].
in vivo
Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice[2].
| Animal Model: | Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein[2] |
| Dosage: | 2.5 mg/kg body weight per injection |
| Administration: | Intraperitoneally every 2 days for 15 days (total, eight doses) |
| Result: | A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed. |
IC 50
Topoisomerase I
References
[1] Bala?a-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454
Indotecan Preparation Products And Raw materials
Raw materials
Preparation Products
Indotecan Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
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- 32435
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- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
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- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
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