ChemicalBook > CAS DataBase List > ABP688
ABP688
- Product Name
- ABP688
- CAS No.
- 924298-51-1
- Chemical Name
- ABP688
- Synonyms
- ABP688;ABP 924298-51-1;ABP688, 10 mM in DMSO;3-((6-Methylpyridin-2-yl)ethynyl)cyclohex-2-en-1-one O-methyl oxime;3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime;2-Cyclohexen-1-one, 3-[2-(6-methyl-2-pyridinyl)ethynyl]-, O-methyloxime
- CBNumber
- CB92669578
- Molecular Formula
- C15H16N2O
- Formula Weight
- 240.3
- MOL File
- 924298-51-1.mol
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ABP688 Property
- Boiling point:
- 361.4±52.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM
- form
- A solid
- pka
- 2.78±0.19(Predicted)
- color
- Light brown to brown
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N-Bromosuccinimide Price
Tocris
- Product number
- 5229
- Product name
- ABP688
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $163
- Updated
- 2021/12/16
Tocris
- Product number
- 5229
- Product name
- ABP688
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $683
- Updated
- 2021/12/16
TRC
- Product number
- A106525
- Product name
- ABP688
- Packaging
- 50mg
- Price
- $580
- Updated
- 2021/12/16
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ABP688 Chemical Properties,Usage,Production
Uses
ABP 688 is a high affinity and selective of metabotropic glutamate receptor (mGluR5). Also, it inhibits glutamate induced calcium release from L(tk-) cells expressing human mGlu5 receptors.
Enzyme inhibitor
This high-affinity mGluR antagonist (FW = 240.31 g/mol; CAS 924298- 51-1; Soluble to 100 mM in DMSO; 50 mM in 1 eq. HCl), also named 3- [2-(6-methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime, targets the human metabolotrophic glutamate receptor-5 (mGluR5) (Ki = 1.7 nM) and inhibits glutamate-induced calcium release from Ltk-cells expressing human mGlu5 receptors (IC50 = 2.3 nM). Indeed, [11C]- ABP688 is a useful PET tracer for in vivo imaging of the mGluR5 in rodents.
IC 50
human mGluR5: 1.7 nM (Ki)
storage
Store at -20°C
ABP688 Preparation Products And Raw materials
Raw materials
Preparation Products
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