1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea
- Product Name
- 1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea
- CAS No.
- 913548-29-5
- Chemical Name
- 1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea
- Synonyms
- APAU;AR-9281;AR-9281, 10 mM in DMSO;Apau (enzyme inhibitor);1-(1-acetylpiperidin-4-yl)-3-(1-adamantyl)urea;1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea;AR-9281; AR 9281; AR9281; APAU (ENZYME INHIBITOR);;Urea, N-(1-acetyl-4-piperidinyl)-N'-tricyclo[3.3.1.13,7]dec-1-yl-;inflammation,AR-9281,AR9281,hypertension,MsEH,HsEH,Epoxide Hydrolase,soluble epoxide hydrolase (s-EH),oral,inhibit,Inhibitor,AR 9281,type 2 diabetes
- CBNumber
- CB92688623
- Molecular Formula
- C18H29N3O2
- Formula Weight
- 319.44
- MOL File
- 913548-29-5.mol
1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea Property
- Boiling point:
- 554.1±39.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.0(Max Conc. mg/mL);78.26(Max Conc. mM)
- form
- Solid
- pka
- 13.66±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0034433
- Product name
- AR-9281
- Purity
- 98.12%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea Chemical Properties,Usage,Production
Uses
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].
in vivo
AR-9281 (APAU) (oral, 150-200 mg/dL, for 6 weeks) enhances the therapeutic effects of EETs, slows progression of hyperglycemia, protects the myocyte structure, and reduces Ca2+ dysregulation and SERCA remodeling in hyperglycemic rats[2].
| Animal Model: | T2DM rat model[2] |
| Dosage: | 150-200 mg/dL |
| Administration: | oral(drinking), for 6 weeks |
| Result: | Attenuated the progressive increase of blood glucose concentration and preserved mitochondrial structure and myofibril morphology in cardiac myocytes. Protected the intracellular Ca2+ effector system. Had less downregulation of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) and lowed expression of hypertrophic markers. |
References
[1] Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. DOI:10.1016/j.ejmech.2021.113678
[2] Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H853-62. DOI:10.1152/ajpheart.00154.2012
1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea Preparation Products And Raw materials
Raw materials
Preparation Products
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