1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide

Product Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide
CAS No.: 1219184-91-4
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide
Synonyms: CCT 031374 hydrobromide;CCT 031374 hydrobromide, 10 mM in DMSO;CCT-031374 hydrobromide (CCT031374 hydrobromide);1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide;inhibit,Beta catenin,CCT031374,CCT 031374 hydrobromide,CCT-031374,Inhibitor,CCT 031374,β-catenin
CBNumber: CB92694794
Molecular Formula: C23H20BrN3O
Formula Weight: 434.3284
MOL File: 1219184-91-4.mol

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1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide Property

storage temp.: Desiccate at RT
solubility: <21.72mg/ml in DMSO
form: solid
color: Pale yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4675
Product name: CCT031374hydrobromide
Purity: ≥98%(HPLC)
Packaging: 10
Price: $189
Updated: 2021/12/16

Tocris

Product number: 4675
Product name: CCT031374hydrobromide
Purity: ≥98%(HPLC)
Packaging: 50
Price: $773
Updated: 2021/12/16

Usbiological

Product number: 254906
Product name: CCT 031374 hydrobromide
Packaging: 10mg
Price: $432
Updated: 2021/12/16

Usbiological

Product number: 145666
Product name: CCT 031374 hydrobromide
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: B397880
Product name: 1-[1,1''-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanoneHydrobromide
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide Chemical Properties,Usage,Production

Uses

1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone hydrobromide is an inhibitor of TCF-dependent transcription. CCT 031374 was also shown to increase turnover of β-catenin.

Biological Activity

cct 031374 hydrobromide is a selective inhibitor of wnt/β-catenin signaling pathway [1].the wnt/β-catenin pathway is activated by the binding of wnt ligand to a complex comprising lrp5/6 and frizzled (fz) receptors and then activates transcription factor/β-catenin-dependent transcription [1].cct 031374 hydrobromide is a selective wnt/β-catenin signaling pathway inhibitor. cct031374 inhibited bio-induced β-catenin accumulation in l-cells with ic50 value of 6.1 μm. in hct116 human colon cancer cell line, cct031374 inhibited cell proliferation by inducing apoptosis. in mouse l-cells, bio, a gsk-3 inhibitor, significantly increased total β-catenin levels. while cct031374 inhibited bio-induced accumulation of β-catenin in both nuclear and cytosolic. in u2os gfp-β-catenin human osteosarcoma cells, cct031374 induced the formation of gfp-β-catenin aggregates. in human neurogenic embryoid bodies, cct031374 reduced the mrna levels of endogenous lef1. also, cct031374 inhibited cell growth with gi values of 11.5, 13.9, 13.2, 9.6 and 44 μm in ht29, hct116, sw480, snu475 and ccd841co cancer cell lines, respectively [1].

References

[1]. ewan k, pajak b, stubbs m, et al. a useful approach to identify novel small-molecule inhibitors of wnt-dependent transcription. cancer res, 2010, 70(14): 5963-5973.

1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide Preparation Products And Raw materials

Raw materials

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1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMide Suppliers

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1219184-91-4, 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-iMidazo[1,2-a]benziMidazol-9-yl)-ethanone HydrobroMideRelated Search:

CCT 031374 hydrobromide

CCT-031374 hydrobromide (CCT031374 hydrobromide)

inhibit,Beta catenin,CCT031374,CCT 031374 hydrobromide,CCT-031374,Inhibitor,CCT 031374,β-catenin

1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide

CCT 031374 hydrobromide, 10 mM in DMSO

1219184-91-4

C23H19N3OHBr

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals