UNC0379
- Product Name
- UNC0379
- CAS No.
- 1620401-82-2
- Chemical Name
- UNC0379
- Synonyms
- UNC03;CS-1767;UNC0379;UNC0379, >=98%;UNC0379 ，S7570;UNC0379 USP/EP/BP;UNC 0379; UNC-0379;UNC0379, 10 mM in DMSO;UNC0379, UNC-0379, UNC 0379;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
- CBNumber
- CB92715675
- Molecular Formula
- C23H35N5O2
- Formula Weight
- 413.56
- MOL File
- 1620401-82-2.mol
UNC0379 Property
- Boiling point:
- 606.3±65.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- pka
- 10.54±0.20(Predicted)
- form
- solid
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16400
- Product name
- UNC0379
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 16400
- Product name
- UNC0379
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 16400
- Product name
- UNC0379
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $298
- Updated
- 2024/03/01
- Product number
- FU137732
- Product name
- UNC 0379 NEW
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CS-3345
- Product name
- UNC0379
- Purity
- 99.75%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
UNC0379 Chemical Properties,Usage,Production
Description
UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2
Uses
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].
in vivo
UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse[3].
| Animal Model: | Bleomycin (BLM)-induced lung fibrosis mouse model[3] |
| Dosage: | 1 mg/kg/day |
| Administration: | Intratracheal administration, on day7, 8, and 9. |
| Result: | Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation. |
IC 50
SETD8/KMT5A
References
[1] ANQI MA. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8[J]. Journal of Medicinal Chemistry, 2014, 57 15: 6822-6833. DOI:10.1021/jm500871s
[2] VERONICA VESCHI. Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.[J]. Cancer Cell, 2017, 31 1 1: 50-63. DOI:10.1016/j.ccell.2016.12.002
UNC0379 Preparation Products And Raw materials
Raw materials
Preparation Products
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