Methyl 2-ethynylisonicotinate
- Product Name
- Methyl 2-ethynylisonicotinate
- CAS No.
- 1256810-92-0
- Chemical Name
- Methyl 2-ethynylisonicotinate
- Synonyms
- Methyl 2-ethynylisonicotinate;Methyl 2-ethynyl-4-pyridinecarboxylate;Methyl 2-ethynylisonicotinate - [M51179];4-Pyridinecarboxylic acid, 2-ethynyl-, methyl ester
- CBNumber
- CB92716894
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 1256810-92-0.mol
Methyl 2-ethynylisonicotinate Property
- Boiling point:
- 271.1±25.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.15±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- M51179
- Product name
- Methyl2-ethynylisonicotinate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- M51179
- Product name
- Methyl2-ethynylisonicotinate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- AS44930
- Product name
- Methyl 2-ethynylisonicotinate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $188
- Updated
- 2021/12/16
- Product number
- AS44930
- Product name
- Methyl 2-ethynylisonicotinate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- M51179
- Product name
- Methyl2-ethynylisonicotinate
- Purity
- 98%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
Methyl 2-ethynylisonicotinate Chemical Properties,Usage,Production
Synthesis
499193-51-0
1256810-92-0
Methyl 2-((trimethylsilyl)ethynyl)isonicotinate (8.00 g, 34.2 mmol) was used as the raw material, which was dissolved in THF (150 mL), and TBAF (1.0 M solution of THF, 51.4 mL, 51.4 mmol) was added slowly at 0°C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (50 mL) and washed with 10% NaHCO3 solution (50 mL). The organic layer was separated, dried with anhydrous MgSO4 and concentrated under reduced pressure to give a dark brown to black residue. The residue was loaded on silica gel and purified by column chromatography (SiO2, eluent: 0-20% ethyl acetate/petroleum ether, 40-60°C) to afford the target product methyl 2-alkynylisonicotinate (4.5 g, 81% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ 8.73 (dd, J = 5.1, 0.9 Hz, 1H), 8.01 (dd, J = 5.1, 0.9 Hz, 1H), 8.01 (dd, J = 5.1, 0.9 Hz). 8.01 (dd, J = 1.5, 0.9 Hz, 1H), 7.80 (dd, J = 5.1, 1.6 Hz, 1H), 3.95 (s, 3H), 3.22 (s, 1H).
References
[1] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 145; 146
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 148
Methyl 2-ethynylisonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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