Methyl 4-chloro-6-Methoxypicolinate

Product Name: Methyl 4-chloro-6-Methoxypicolinate
CAS No.: 204378-37-0
Chemical Name: Methyl 4-chloro-6-Methoxypicolinate
Synonyms: Regorafenib Impurity 125;Levocarnitine Impurity 49;Methyl 4-chloro-6-Methoxypicolinate;2-Pyridinecarboxylic acid, 4-chloro-6-methoxy-, methyl ester
CBNumber: CB92732933
Molecular Formula: C8H8ClNO3
Formula Weight: 201.61
MOL File: 204378-37-0.mol

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Methyl 4-chloro-6-Methoxypicolinate Property

Boiling point:: 290.8±35.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.53±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M342768
Product name: Methyl4-chloro-6-methoxypicolinate
Packaging: 100mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 0973DU
Product name: Methyl4-chloro-6-methoxypicolinate
Packaging: 250mg
Price: $599
Updated: 2021/12/16

Matrix Scientific

Product number: 153540
Product name: Methyl 4-chloro-6-methoxypicolinate
Purity: 95%
Packaging: 1g
Price: $5550
Updated: 2021/12/16

Ambeed

Product number: A206198
Product name: Methyl4-chloro-6-methoxypicolinate
Purity: 95%
Packaging: 100mg
Price: $160
Updated: 2021/12/16

Alichem

Product number: 204378370
Product name: Methyl4-chloro-6-methoxypyridine-2-carboxylate
Packaging: 250mg
Price: $680
Updated: 2021/12/16

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Methyl 4-chloro-6-Methoxypicolinate Chemical Properties,Usage,Production

Synthesis

1443759-42-9

204378-37-0

General procedure for the synthesis of methyl 4-chloro-6-methoxypyridine-2-carboxylate from methyl 4-amino-6-methoxy-pyridine-2-carboxylate: to a mixture of 1.25 mL (10.5 mmol) of tert-butyl nitrite and 1.42 g (10.5 mmol) of copper(II) chloride in 40 mL of acetonitrile was added slowly, dropwise, at 40 °C, 1.20 g (6.59 mmol) of 4- methyl amino-6-methoxy-pyridine-2-carboxylate dissolved in 10 mL of acetonitrile. The reaction mixture was stirred at 80 °C for 1 h and then poured into ice water, acidified with 4 M aqueous HCl and extracted with EtOAc. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by fast chromatography (eluent ratio: petroleum ether/EtOAc 3/1→2/1). A product of 650 mg was obtained in 49% yield. eSI-MS: m/z = 202 (M + H)+. hPLC retention time: 1.12 min (Method 5).

References

[1] Patent: WO2013/87805, 2013, A1. Location in patent: Page/Page column 75
[2] Patent: US2013/158042, 2013, A1. Location in patent: Paragraph 0477; 0478; 0479; 0480; 0481

Methyl 4-chloro-6-Methoxypicolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-chloro-6-Methoxypicolinate Suppliers

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Methyl 4-chloro-6-Methoxypicolinate

2-Pyridinecarboxylic acid, 4-chloro-6-methoxy-, methyl ester

Regorafenib Impurity 125

Levocarnitine Impurity 49

204378-37-0