N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide

ChemicalBook > CAS DataBase List > N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide

N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide

Product Name: N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
CAS No.: 329059-55-4
Chemical Name: N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
Synonyms: BRD7116;BRD7716;BRD-7116;BRD 7116;BRD7116 >=98% (HPLC);BRD7116;BRD-7116;BRD 7116;BRD 7116,Bacterial,BRD7116,inhibit,BRD-7116,Inhibitor;N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide;N,N'-(Sulfonylbis(4,1-phenylene))bis(2,2,3,3-tetramethylcyclopropane-1-carboxamide);N,N'-(Sulfonylbis(4,1-phenylene))bis(2,2,3,3-tetramethylcyclopropane-1-carboxamide);Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)
CBNumber: CB92750612
Molecular Formula: C28H36N2O4S
Formula Weight: 496.66
MOL File: 329059-55-4.mol

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N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide Property

storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1080
Product name: BRD7116
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1080
Product name: BRD7116
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $423
Updated: 2022/05/15

Cayman Chemical

Product number: 20570
Product name: BRD7116
Purity: ≥98%
Packaging: 5mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 20570
Product name: BRD7116
Purity: ≥98%
Packaging: 50 mg
Price: $382
Updated: 2024/03/01

Cayman Chemical

Product number: 20570
Product name: BRD7116
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2023/01/06

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N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide Chemical Properties,Usage,Production

Description

BRD 7116 (329059-55-4) inhibits leukemia stem cell (LSC) activity (EC50 = 200 nM). Displays a >100-fold selectivity for LSCs over normal hematopoietic stem cells.1

Uses

BRD 7116 inhibits LSCe (leukemia stem cell) and HSPCs (Hematopoietic stem cells ), by displaying cell-non-autonomous anti-leukemia activity.

Definition

ChEBI: 2,2,3,3-tetramethyl-N-[4-[4-[[oxo-(2,2,3,3-tetramethylcyclopropyl)methyl]amino]phenyl]sulfonylphenyl]-1-cyclopropanecarboxamide is an anilide.

storage

+4°C

References

1) Hartwell et al. (2013), Niche-based screening identifies small-molecule inhibitors of leukemia stem cells; Nat. Chem. Biol., 9 840

N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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329059-55-4, N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamideRelated Search:

CYCLOPAMINE TYRPHOSTIN AG 1296 (+)-Camptothecin Sunitinib Malate

2,2,3,3-Tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide

BRD7116

BRD7116;BRD-7116;BRD 7116

N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide

BRD7716

BRD-7116;BRD 7116

Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)

BRD7116 >=98% (HPLC)

N,N'-(Sulfonylbis(4,1-phenylene))bis(2,2,3,3-tetramethylcyclopropane-1-carboxamide)

BRD 7116,Bacterial,BRD7116,inhibit,BRD-7116,Inhibitor

N,N'-(Sulfonylbis(4,1-phenylene))bis(2,2,3,3-tetramethylcyclopropane-1-carboxamide)

329059-55-4

Inhibitors