ChemicalBook > CAS DataBase List > 4-Amino-3-chlorobenzonitrile

4-Amino-3-chlorobenzonitrile

Product Name
4-Amino-3-chlorobenzonitrile
CAS No.
21803-75-8
Chemical Name
4-Amino-3-chlorobenzonitrile
Synonyms
BUTTPARK 29\06-54;2-CHLORO-4-CYANOANILINE;3-CHLORO-4-AMINBENZONITRILE;4-AMINO-3-CHLOROBENZONITRILE;3-CHLORO-4-AMINOBENZONITRILE;4-amino-3-chlorobenoznitrile;1-aMino-2-chloro-4-cyanobenzene;Benzonitrile, 4-amino-3-chloro-;4-Amino-3-chlorobenzonitrile >4-Amino-3-chlorobenzonitrile,97%
CBNumber
CB9298307
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
21803-75-8.mol
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4-Amino-3-chlorobenzonitrile Property

Melting point:
102-105 °C(lit.)
Boiling point:
277.8±25.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-0.22±0.10(Predicted)
color 
Light yellow to Brown to Dark green
BRN 
1817655
CAS DataBase Reference
21803-75-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36/37-36/37/39
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful/Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
519596
Product name
4-Amino-3-chlorobenzonitrile
Purity
97%
Packaging
5g
Price
$178
Updated
2025/07/31
Sigma-Aldrich
Product number
519596
Product name
4-Amino-3-chlorobenzonitrile
Purity
97%
Packaging
25g
Price
$604
Updated
2023/06/20
TCI Chemical
Product number
A1962
Product name
4-Amino-3-chlorobenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
A1962
Product name
4-Amino-3-chlorobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$258
Updated
2023/01/07
TRC
Product number
A578308
Product name
4-Amino-3-chlorobenzonitrile
Packaging
5g
Price
$60
Updated
2021/12/16
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4-Amino-3-chlorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Definition

ChEBI: 4-Amino-3-chlorobenzonitrile is a member of benzenes and a nitrile.

Synthesis

873-74-5

21803-75-8

Step 1: N-chlorosuccinimide (12.4 g, 93 mmol) was slowly added to a stirred solution of 4-aminobenzonitrile (10.0 g, 84.7 mmol) in acetonitrile (100 mL) at 90 °C. After the addition was completed, the reaction mixture was stirred continuously at 90 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in 500 mL of dichloromethane and washed with 5% aqueous sodium hydroxide. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 4-amino-3-chlorobenzonitrile as a brown solid (12.2 g, 95% yield).1H NMR (300 MHz, CDCl3) δ 7.54 (d, J = 1.7 Hz, 1H), 7.35 (dd, J = 1.8,8.4 Hz, 1H), 6.77 (d, J = 8.5 Hz, 1H ), 4.63 (br s, 2H).

References

[1] Synlett, 1999, # 12, p. 1984 - 1986
[2] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0383
[3] Journal of Organic Chemistry, 2017, vol. 82, # 14, p. 7529 - 7537
[4] Organic Letters, 2008, vol. 10, # 1, p. 113 - 116
[5] Synthesis, 1985, # 6/7, p. 669 - 670

4-Amino-3-chlorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-3-chlorobenzonitrile manufacturers

Career Henan Chemical Co
Product
4-Amino-3-chlorobenzonitrile 21803-75-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

21803-75-8, 4-Amino-3-chlorobenzonitrileRelated Search:

Glucosamine p-Tolunitrile 3-Aminophenol ALTRENOGEST 4-Aminobenzonitrile EC 2.6.1.2 Acetaminophen 2-Chlorobenzonitrile Sulfamic acid Benzonitrile 4-Nitrobenzonitrile 6-Aminocaproic acid 3-Aminopyridine 2-Cyanophenol 4-Chlorobenzonitrile Glycine Tris(hydroxymethyl)aminomethane Difluorochloromethane

  • BUTTPARK 29\06-54
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  • 21803-75-8
  • Building Blocks
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  • Nitrogen Compounds
  • Organic Building Blocks
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