ChemicalBook > CAS DataBase List > [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

Product Name
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
CAS No.
1380548-02-6
Chemical Name
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Synonyms
SR10067;SR10067, 10 mM in DMSO;REV-ERB Agonist, SR10067;(3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone;[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone;Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-;brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
CBNumber
CB93039833
Molecular Formula
C31H31NO3
Formula Weight
465.58
MOL File
1380548-02-6.mol
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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Property

Boiling point:
648.1±50.0 °C(Predicted)
Density 
1.159±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
-2.05±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6038
Product name
SR10067
Purity
≥98%(HPLC)
Packaging
10
Price
$157
Updated
2021/12/16
Tocris
Product number
6038
Product name
SR10067
Purity
≥98%(HPLC)
Packaging
50
Price
$662
Updated
2021/12/16
TRC
Product number
S684498
Product name
SR10067
Packaging
50mg
Price
$630
Updated
2021/12/16
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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Chemical Properties,Usage,Production

Uses

SR 10067 is a novel Rev-erbα agonist.

Biological Activity

Cell permeable: yes', 'Primary Target
REV-ERB', 'Reversible: yes', 'Target IC50: 170 nM for REV-ERB&alpha

in vivo

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1].

Animal Model:Mice[1]
Dosage:30 mg/kg
Administration:i.p.
Result:Remained above the IC50 of the receptor in plasma and brain concentrations.
Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity.
Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.

storage

Store at -20°C

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Suppliers

China 26 United Kingdom 1 United States 4 Global 31
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1380548-02-6, [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanoneRelated Search:


  • [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
  • SR10067
  • Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-
  • brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
  • (3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone
  • SR10067, 10 mM in DMSO
  • REV-ERB Agonist, SR10067
  • 1380548-02-6