ChemicalBook > CAS DataBase List > [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
- Product Name
- [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
- CAS No.
- 1380548-02-6
- Chemical Name
- [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
- Synonyms
- SR10067;SR10067, 10 mM in DMSO;REV-ERB Agonist, SR10067;(3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone;[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone;Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-;brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
- CBNumber
- CB93039833
- Molecular Formula
- C31H31NO3
- Formula Weight
- 465.58
- MOL File
- 1380548-02-6.mol
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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Property
- Boiling point:
- 648.1±50.0 °C(Predicted)
- Density
- 1.159±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- -2.05±0.40(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Tocris
- Product number
- 6038
- Product name
- SR10067
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $157
- Updated
- 2021/12/16
Tocris
- Product number
- 6038
- Product name
- SR10067
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $662
- Updated
- 2021/12/16
TRC
- Product number
- S684498
- Product name
- SR10067
- Packaging
- 50mg
- Price
- $630
- Updated
- 2021/12/16
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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Chemical Properties,Usage,Production
Uses
SR 10067 is a novel Rev-erbα agonist.
Biological Activity
Cell permeable: yes', 'Primary Target
REV-ERB', 'Reversible: yes', 'Target IC50: 170 nM for REV-ERB&alpha
in vivo
SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1].
| Animal Model: | Mice[1] |
| Dosage: | 30 mg/kg |
| Administration: | i.p. |
| Result: | Remained above the IC50 of the receptor in plasma and brain concentrations. Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity. |
storage
Store at -20°C
[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77