[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

Product Name: [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
CAS No.: 1380548-02-6
Chemical Name: [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Synonyms: SR10067;SR10067, 10 mM in DMSO;REV-ERB Agonist, SR10067;(3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone;[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone;Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-;brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor
CBNumber: CB93039833
Molecular Formula: C31H31NO3
Formula Weight: 465.58
MOL File: 1380548-02-6.mol

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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Property

Boiling point:: 648.1±50.0 °C(Predicted)
Density: 1.159±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: -2.05±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6038
Product name: SR10067
Purity: ≥98%(HPLC)
Packaging: 10
Price: $157
Updated: 2021/12/16

Tocris

Product number: 6038
Product name: SR10067
Purity: ≥98%(HPLC)
Packaging: 50
Price: $662
Updated: 2021/12/16

TRC

Product number: S684498
Product name: SR10067
Packaging: 50mg
Price: $630
Updated: 2021/12/16

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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Chemical Properties,Usage,Production

Uses

SR 10067 is a novel Rev-erbα agonist.

Biological Activity

Cell permeable: yes', 'Primary Target
REV-ERB', 'Reversible: yes', 'Target IC50: 170 nM for REV-ERB&alpha

in vivo

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse^[1].

Animal Model:	Mice^[1]
Dosage:	30 mg/kg
Administration:	i.p.
Result:	Remained above the IC₅₀ of the receptor in plasma and brain concentrations. Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.

storage

Store at -20°C

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone Suppliers

China 26 United Kingdom 1 United States 4 Global 31

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
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Aladdin Scientific

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ProdList: 57505
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MedChemExpress

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1380548-02-6, [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanoneRelated Search:

[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone

SR10067

Methanone, [3-[[4-(1,1-dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenyl-

brain penetrant,inhibit,Rev-Erbβ,REV-ERB,SR 10067,Rev-Erbα,SR10067,neuropsychiatric disorders,SR-10067,metabolic diseases,Inhibitor

(3-((4-(tert-Butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone

SR10067, 10 mM in DMSO

REV-ERB Agonist, SR10067

1380548-02-6