Chloroacetamido-PEG4-t-Butyl Ester

Product Name: Chloroacetamido-PEG4-t-Butyl Ester
CAS No.: 1365655-90-8
Chemical Name: Chloroacetamido-PEG4-t-Butyl Ester
Synonyms: CAS_1365655-90-8;Chloroacetamido-PEG4-C2-Boc;Chloroacetamido-PEG4-t-Butyl Ester;tert-Butyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate;4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-chloro-17-oxo-, 1,1-dimethylethyl ester
CBNumber: CB93062464
Molecular Formula: C17H32ClNO7
Formula Weight: 397.89
MOL File: 1365655-90-8.mol

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Chloroacetamido-PEG4-t-Butyl Ester Property

Boiling point:: 527.6±50.0 °C(Predicted)
Density: 1.119±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
form: Liquid
pka: 13.57±0.46(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C384078
Product name: Chloroacetamido-PEG4-t-ButylEster
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-20577
Product name: Chloroacetamido-PEG4-t-ButylEster
Purity: 98%
Packaging: 250mg
Price: $270
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1369
Product name: Chloroacetamido-PEG4-t-Butyl Ester
Packaging: 250mg
Price: $526
Updated: 2021/12/16

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Chloroacetamido-PEG4-t-Butyl Ester Chemical Properties,Usage,Production

Description

Chloroacetamido-PEG4-t-Butyl Ester is a PEG linker containing a chloroacetamide and a t-butyl ester. The chlorine is a good leaving group and can undergo substitution reactions. The t-butyl group is an acid labile protecting group. Upon removal, the carboxylic acid can be further reacted. The hydrophilic PEG chain increases the water solubilty of compounds in aqueous media.

Uses

Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

PEGs; Alkyl/ether

References

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1021/jm2009106

Chloroacetamido-PEG4-t-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloroacetamido-PEG4-t-Butyl Ester Suppliers

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1365655-90-8, Chloroacetamido-PEG4-t-Butyl EsterRelated Search:

Methyl chloroacetate Trichloroacetonitrile

Chloroacetamido-PEG4-t-Butyl Ester

CAS_1365655-90-8

Chloroacetamido-PEG4-C2-Boc

4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-chloro-17-oxo-, 1,1-dimethylethyl ester

tert-Butyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate

1365655-90-8

C17H32ClNO7