4-Chloro-6-methoxy-2-methylquinazoline

Product Name: 4-Chloro-6-methoxy-2-methylquinazoline
CAS No.: 60395-90-6
Chemical Name: 4-Chloro-6-methoxy-2-methylquinazoline
Synonyms: 4-Chloro-6-methoxy-2-methylquinazoline;Quinazoline, 4-chloro-6-methoxy-2-methyl-
CBNumber: CB93065021
Molecular Formula: C10H9ClN2O
Formula Weight: 208.64
MOL File: 60395-90-6.mol

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4-Chloro-6-methoxy-2-methylquinazoline Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to khaki Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C377170
Product name: 4-chloro-6-methoxy-2-methylquinazoline
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C377170
Product name: 4-chloro-6-methoxy-2-methylquinazoline
Packaging: 25mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 4776CT
Product name: 4-Chloro-6-methoxy-2-methylquinazoline
Packaging: 1g
Price: $448
Updated: 2021/12/16

Chemenu

Product number: CM123372
Product name: 4-chloro-6-methoxy-2-methylquinazoline
Purity: 97%
Packaging: 5g
Price: $813
Updated: 2021/12/16

Ambeed

Product number: A444705
Product name: 4-Chloro-6-methoxy-2-methylquinazoline
Purity: 97%
Packaging: 5g
Price: $853
Updated: 2021/12/16

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4-Chloro-6-methoxy-2-methylquinazoline Chemical Properties,Usage,Production

Synthesis

51413-71-9

60395-90-6

6-Methoxy-2-methylquinazolin-4-ol (233 mg, 1.23 mmol) was used as starting material and suspended in phosphoryl chloride (POCl3, 10 mL, 108 mmol). The reaction mixture was stirred under reflux conditions for 2.5 days and a gradual transformation of the suspension into a reddish brown solution was observed. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphoryl chloride was subsequently removed by evaporation under reduced pressure. The residue was partitioned between 5% aqueous sodium bicarbonate solution (NaHCO3, 100 mL) and ethyl acetate (100 mL) for extraction. The organic layer was washed sequentially with 5% aqueous sodium bicarbonate solution (100 mL) and pure water (100 mL). The washed organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using cyclohexane/ethyl acetate as eluent. The final target product, 4-chloro-6-methoxy-2-methylquinazoline, was obtained as a white solid (142 mg, 0.681 mmol) in 56% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and UPLC-MS (ESI): 1H NMR δ 7.92 (d, J = 9.1 Hz, 1H), 7.70 (dd, J = 9.1, 2.8 Hz, 1H), 7.42 (d, J = 2.8 Hz, 1H), 3.96 (s, 3H), 2.71 (s, 3H); UPLC-MS (ESI) RT 3.88 min, m/z 209 [M + H]+ (purity >95%).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 890 - 901

4-Chloro-6-methoxy-2-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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60395-90-6, 4-Chloro-6-methoxy-2-methylquinazolineRelated Search:

4-Chloro-6-methoxy-2-methylquinazoline

Quinazoline, 4-chloro-6-methoxy-2-methyl-

60395-90-6