4-Chloro-6-methoxy-2-methylquinazoline
- Product Name
- 4-Chloro-6-methoxy-2-methylquinazoline
- CAS No.
- 60395-90-6
- Chemical Name
- 4-Chloro-6-methoxy-2-methylquinazoline
- Synonyms
- 4-Chloro-6-methoxy-2-methylquinazoline;Quinazoline, 4-chloro-6-methoxy-2-methyl-
- CBNumber
- CB93065021
- Molecular Formula
- C10H9ClN2O
- Formula Weight
- 208.64
- MOL File
- 60395-90-6.mol
4-Chloro-6-methoxy-2-methylquinazoline Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to khaki Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C377170
- Product name
- 4-chloro-6-methoxy-2-methylquinazoline
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C377170
- Product name
- 4-chloro-6-methoxy-2-methylquinazoline
- Packaging
- 25mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 4776CT
- Product name
- 4-Chloro-6-methoxy-2-methylquinazoline
- Packaging
- 1g
- Price
- $448
- Updated
- 2021/12/16
- Product number
- CM123372
- Product name
- 4-chloro-6-methoxy-2-methylquinazoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $813
- Updated
- 2021/12/16
- Product number
- A444705
- Product name
- 4-Chloro-6-methoxy-2-methylquinazoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $853
- Updated
- 2021/12/16
4-Chloro-6-methoxy-2-methylquinazoline Chemical Properties,Usage,Production
Synthesis
51413-71-9
60395-90-6
6-Methoxy-2-methylquinazolin-4-ol (233 mg, 1.23 mmol) was used as starting material and suspended in phosphoryl chloride (POCl3, 10 mL, 108 mmol). The reaction mixture was stirred under reflux conditions for 2.5 days and a gradual transformation of the suspension into a reddish brown solution was observed. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphoryl chloride was subsequently removed by evaporation under reduced pressure. The residue was partitioned between 5% aqueous sodium bicarbonate solution (NaHCO3, 100 mL) and ethyl acetate (100 mL) for extraction. The organic layer was washed sequentially with 5% aqueous sodium bicarbonate solution (100 mL) and pure water (100 mL). The washed organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using cyclohexane/ethyl acetate as eluent. The final target product, 4-chloro-6-methoxy-2-methylquinazoline, was obtained as a white solid (142 mg, 0.681 mmol) in 56% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and UPLC-MS (ESI): 1H NMR δ 7.92 (d, J = 9.1 Hz, 1H), 7.70 (dd, J = 9.1, 2.8 Hz, 1H), 7.42 (d, J = 2.8 Hz, 1H), 3.96 (s, 3H), 2.71 (s, 3H); UPLC-MS (ESI) RT 3.88 min, m/z 209 [M + H]+ (purity >95%).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 890 - 901
4-Chloro-6-methoxy-2-methylquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-6-methoxy-2-methylquinazoline Suppliers
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