Glesatinib (hydrochloride)

Product Name: Glesatinib (hydrochloride)
CAS No.: 1123838-51-6
Chemical Name: Glesatinib (hydrochloride)
Synonyms: CS-2642;Glesatinib HCl;MGCD-265 HYDROCHLORIDE;Glesatinib (hydrochloride);Glesatinib (hydrochloride)(MGCD265 hydrochloride)
CBNumber: CB93121101
Molecular Formula: C31H28ClF2N5O3S2
Formula Weight: 656.16
MOL File: 1123838-51-6.mol

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Glesatinib (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 28 mg/mL (42.67 mM)
form: Solid
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5530
Product name: Glesatinib(hydrochloride)
Purity: 98.25%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-5530
Product name: Glesatinib(hydrochloride)
Purity: 98.25%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-5530
Product name: Glesatinib(hydrochloride)
Purity: 98.25%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611465
Product name: Glesatinib hydrochloride
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611465
Product name: Glesatinib hydrochloride
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

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Glesatinib (hydrochloride) Chemical Properties,Usage,Production

Description

Glesatinib HCl is a novel potent MET/SMO dual inhibitor.

Uses

Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent MET/SMO dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC)[1][2].

in vivo

Glesatinib hydrochloride (MGCD265 hydrochloride; 15 mg/kg/day; orally; 40 weeks) causes a significant decrease in tumor size^[1].

Animal Model:	4?6-week old female balb/c athymic (nu/nu) mice with HCC827 NSCLC tumor xenografts^[1]
Dosage:	15 mg/kg
Administration:	Orally; daily; 40 weeks
Result:	Caused a significant decrease in tumor size.

References

[1] Morgillo F, et al. Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer. J Med Chem. 2017 Sep 14;60(17):7447-7458. DOI:10.1021/acs.jmedchem.7b00794
[2] Cui Q, et al. Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated MultidrugResistance in Cancer Cells. Front Oncol. 2019 Apr 25;9:313. DOI:10.3389/fonc.2019.00313

Glesatinib (hydrochloride) Preparation Products And Raw materials

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Preparation Products

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Glesatinib (hydrochloride) Suppliers

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1123838-51-6, Glesatinib (hydrochloride)Related Search:

Glesatinib (hydrochloride)

Glesatinib HCl

MGCD-265 HYDROCHLORIDE

CS-2642

Glesatinib (hydrochloride)(MGCD265 hydrochloride)

1123838-51-6