2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine
- Product Name
- 2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine
- CAS No.
- 1157012-67-3
- Chemical Name
- 2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine
- Synonyms
- 5-Amino-1-(tetrahydro-2H-pyran-4-yl)pyrazole;2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine;1H-Pyrazol-5-amine, 1-(tetrahydro-2H-pyran-4-yl)-;1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine 97%
- CBNumber
- CB93145615
- Molecular Formula
- C8H13N3O
- Formula Weight
- 167.21
- MOL File
- 1157012-67-3.mol
2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine Property
- Boiling point:
- 355.0±32.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.79±0.19(Predicted)
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- OR306159
- Product name
- 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- OR306159
- Product name
- 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 9114DE
- Product name
- 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine
- Packaging
- 250mg
- Price
- $399
- Updated
- 2021/12/16
- Product number
- OR306159
- Product name
- 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine
- Packaging
- 1g
- Price
- $681
- Updated
- 2021/12/16
- Product number
- 177229
- Product name
- 1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-5-amine
- Packaging
- 1g
- Price
- $720
- Updated
- 2021/12/16
2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine Chemical Properties,Usage,Production
Synthesis
29943-42-8
353-07-1
1157012-67-3
3-Hydrazinylpropionitrile (3.40 g, 40 mmol) was added slowly and dropwise to a solution of tetrahydropyran-4-one (4.00 g, 40 mmol) in ethanol (40 mL) at room temperature. The reaction mixture was stirred at room temperature for 3 hours. Subsequently, the mixture was concentrated under reduced pressure and the residue was dissolved in n-butanol (80 mL) and sodium methanolate (4.32 g, 80 mmol) was added. The mixture was refluxed overnight. After the reaction was complete, the mixture was concentrated under reduced pressure. The residue was treated with a solution of saturated sodium bicarbonate and ammonium chloride (80 mL). The aqueous phase was extracted with dichloromethane (60 mL × 2) and the combined organic phases were dried with anhydrous sodium sulfate. The organic phase was concentrated and the residue was purified by fast column chromatography (acetonitrile/water = 30%) to afford 5.34 g of crude 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine as a yellow solid. Mass spectrometry analysis showed m/z 168.3 ([M + H]+).
References
[1] Patent: WO2016/123392, 2016, A2. Location in patent: Paragraph 00544
2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(Tetrahydro-pyran-4-yl)-2H-pyrazol-3-ylamine Suppliers
- Tel
- 13564638271
- Fax
- 021-68948280
- shhjiang1977@163.com
- Country
- China
- ProdList
- 2987
- Advantage
- 55
- Tel
- 15902830537
- zhanghao@happysyn.com
- Country
- China
- ProdList
- 3181
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 8840
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12884
- Advantage
- 58
- Tel
- 18061688856
- easichem@126.com
- Country
- China
- ProdList
- 477
- Advantage
- 58
- Tel
- 0531-0000
- thinklifescience@163.com
- Country
- China
- ProdList
- 19689
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58