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SCH 529074

Product Name
SCH 529074
CAS No.
922150-11-6
Chemical Name
SCH 529074
Synonyms
SCH 529074;N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine;N1-(2-((4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine;1,3-Propanediamine, N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-
CBNumber
CB93146379
Molecular Formula
C31H36Cl2N6
Formula Weight
563.56
MOL File
922150-11-6.mol
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SCH 529074 Property

Boiling point:
640.3±55.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml
form 
A crystalline solid
pka
9.44±0.28(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21552
Product name
SCH 529074
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21552
Product name
SCH 529074
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21552
Product name
SCH 529074
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21552
Product name
SCH 529074
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
Tocris
Product number
4240
Product name
SCH529074
Purity
≥98%(HPLC)
Packaging
50
Price
$710
Updated
2021/12/16
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SCH 529074 Chemical Properties,Usage,Production

Description

SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors. SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.

Uses

SCH 529074 is a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquination of wild type p53.

SCH 529074 Preparation Products And Raw materials

Raw materials

Preparation Products

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SCH 529074 Suppliers

China 38 United Kingdom 1 United States 4 Global 43
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

922150-11-6, SCH 529074Related Search:


  • N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
  • SCH 529074
  • 1,3-Propanediamine, N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-
  • N1-(2-((4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine
  • 922150-11-6