CAY10669

Product Name: CAY10669
CAS No.: 1243583-88-1
Chemical Name: CAY10669
Synonyms: CAY10669;CAY-10669,CAY10669;JZTUSBQKQHUSQE-FLIBITNWSA-N;2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-benzoicacid;Benzoic acid, 2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-
CBNumber: CB93152576
Molecular Formula: C20H22O4
Formula Weight: 326.39
MOL File: 1243583-88-1.mol

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CAY10669 Property

Boiling point:: 516.8±50.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form: A crystalline solid
pka: 2.93±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10974
Product name: CAY10669
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 10974
Product name: CAY10669
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 10974
Product name: CAY10669
Purity: ≥98%
Packaging: 10mg
Price: $632
Updated: 2024/03/01

AK Scientific

Product number: 8922DG
Product name: (Z)-2-Hydroxy-6-(4-(pentyloxy)styryl)benzoicacid
Packaging: 10mg
Price: $802
Updated: 2021/12/16

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CAY10669 Chemical Properties,Usage,Production

Description

CAY10669 is an inhibitor of the histone acetyltransferase PCAF.

Uses

CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM[1]. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells[1][2][3].

IC 50

PCAF: 662 μM (IC₅₀)

References

[1] Ghizzoni M, et al., Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorg Med Chem. 2010 Aug 15;18(16):5826-34. DOI:10.1016/j.bmc.2010.06.089
[2] Farr GH 3rd, et al., A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2020 Oct 15;10(1):29. DOI:10.1186/s13395-020-00251-4
[3] Christensen MD, et al., An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA. J Control Release. 2018 Sep 28;286:210-223. DOI:10.1016/j.jconrel.2018.06.030

CAY10669 Preparation Products And Raw materials

Raw materials

Preparation Products

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1243583-88-1, CAY10669Related Search:

CAY10669

JZTUSBQKQHUSQE-FLIBITNWSA-N

CAY-10669,CAY10669

Benzoic acid, 2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-

2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-benzoicacid

1243583-88-1