CAY10669

CAY10669 Property

Boiling point:

516.8±50.0 °C(Predicted)

Density 

1.192±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

form 

A crystalline solid

pka

2.93±0.30(Predicted)

Hazard and Precautionary Statements (GHS)

CAY10669 Chemical Properties,Usage,Production

Description

CAY10669 is an inhibitor of the histone acetyltransferase PCAF.

Uses

CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM[1]. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells[1][2][3].

IC 50

PCAF: 662 μM (IC₅₀)

References

[1] Ghizzoni M, et al., Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorg Med Chem. 2010 Aug 15;18(16):5826-34. DOI:10.1016/j.bmc.2010.06.089
[2] Farr GH 3rd, et al., A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2020 Oct 15;10(1):29. DOI:10.1186/s13395-020-00251-4
[3] Christensen MD, et al., An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA. J Control Release. 2018 Sep 28;286:210-223. DOI:10.1016/j.jconrel.2018.06.030