Florbenazine
- Product Name
- Florbenazine
- CAS No.
- 937245-42-6
- Chemical Name
- Florbenazine
- Synonyms
- Florbenazine;(2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol;2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
- CBNumber
- CB93166380
- Molecular Formula
- C21H32FNO3
- Formula Weight
- 365.48
- MOL File
- 937245-42-6.mol
Florbenazine Property
- Boiling point:
- 496.0±45.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- pka
- 14.75±0.40(Predicted)
- InChI
- InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1
- InChIKey
- GNKGXQHHUUEYQV-BHIYHBOVSA-N
- SMILES
- C12=CC(OC)=C(OCCCF)C=C1CCN1[C@]2([H])C[C@@H](O)[C@H](CC(C)C)C1
Florbenazine Chemical Properties,Usage,Production
Description
Florbenazine (AV-133) is a fluorinated VMAT-2 ligand for PET. It is designed to measure dopaminergic degeneration by in vivo assessment of striat VMAT2 density in patients with Parkinson’s disease (PD). Besides differentiating PD from essential tremor and drug-induced parkinsonism, PET imaging of VMAT2 may help in differentiating Dementia with Lewy Bodies (DLB) from Alzheimer’s disease. AV-45 (florbetapir, AmyvidTM) is the first PET ligand to receive US FDA approval to assess neuritic plaque amyloid[1-2].
References
[1] Andrew Siderowf. “PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer’s disease and Lewy body disorders.” BMC Neurology 14 (2014): 79.
[2] Harsh V Gupta. “Clinicopathological Correlation: Dopamine and Amyloid PET Imaging with Neuropathology in Three Subjects Clinically Diagnosed with Alzheimer’s Disease or Dementia with Lewy Bodies.” Journal of Alzheimer’s Disease 80 4 (2021): 1603–1612.
Florbenazine Preparation Products And Raw materials
Raw materials
Preparation Products
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