6-bromo-4-fluoro-1H-indazol-3-amine

Product Name: 6-bromo-4-fluoro-1H-indazol-3-amine
CAS No.: 1227912-19-7
Chemical Name: 6-bromo-4-fluoro-1H-indazol-3-amine
Synonyms: 6-bromo-4-fluoro-1H-indazol-3-amine;6-bromo-4-fluoro-1H-indazol-4-amine;1H-Indazol-3-amine, 6-bromo-4-fluoro-;6-Bromo-4-fluoro-1H-indazol-3-ylamine
CBNumber: CB93334163
Molecular Formula: C7H5BrFN3
Formula Weight: 230.04
MOL File: 1227912-19-7.mol

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6-bromo-4-fluoro-1H-indazol-3-amine Property

storage temp.: 2-8°C(protect from light)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C7H5BrFN3/c8-3-1-4(9)6-5(2-3)11-12-7(6)10/h1-2H,(H3,10,11,12)
InChIKey: OLSISKHGQBVTEW-UHFFFAOYSA-N
SMILES: N1C2=C(C(F)=CC(Br)=C2)C(N)=N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC201082
Product name: 6-Bromo-4-fluoro-1H-indazol-3-amine
Purity: 97%
Packaging: 250mg
Price: $144
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-B-0D
Product name: 6-Bromo-4-fluoro-1H-indazol-3-amine
Purity: 97%
Packaging: 100mg
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: 0921DP
Product name: 6-Bromo-4-fluoro-1H-indazol-3-amine
Packaging: 100mg
Price: $196
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-B-0D
Product name: 6-Bromo-4-fluoro-1H-indazol-3-amine
Purity: 97%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

Apolloscientific

Product number: PC201082
Product name: 6-Bromo-4-fluoro-1H-indazol-3-amine
Purity: 97%
Packaging: 100mg
Price: $90
Updated: 2021/12/16

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6-bromo-4-fluoro-1H-indazol-3-amine Chemical Properties,Usage,Production

Synthesis

123843-67-4

1227912-19-7

1. 4-Bromo-2,6-difluorobenzonitrile (i-9a) (30 g, 138 mmol) was dissolved in anhydrous ethanol (300 mL) under nitrogen protection. 2. Hydrazine hydrate (NH2NH2-H2O) (27.6 g, 552 mmol) was slowly added dropwise with stirring at room temperature. 3. The reaction mixture was degassed, then heated to 90 °C and stirred to react for 2 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with acetone (180 mL) and allowed to stand overnight. 5. The precipitated solid was collected by filtration and washed with dichloromethane (DCM) to afford the target compound, 6-bromo-4-fluoro-1H-indazol-3-amine (i-9b) (30 g, 94% yield), as a white solid. 6. The molecular ions were analyzed by LCMS (ESI), measuring the peak [M+H]+ was 230, which was consistent with the theoretically calculated value of C7H5BrFN3 .

References

[1] Patent: WO2014/28591, 2014, A2. Location in patent: Page/Page column 50
[2] Patent: US2015/210687, 2015, A1. Location in patent: Paragraph 0261
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3782 - 3786

6-bromo-4-fluoro-1H-indazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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