2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

Product Name: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
CAS No.: 13600-42-5
Chemical Name: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
Synonyms: 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile;BUTTPARK 43\57-39;IFLAB-BB F2108-0099;2,6-Dichloro-4-(Trifluoromethy;,6-Dichloro-4-(trifluoromethyl)nicotinonitrile;2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine;3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98%;3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%
CBNumber: CB9351572
Molecular Formula: C7HCl2F3N2
Formula Weight: 241
MOL File: 13600-42-5.mol

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2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Property

Melting point:: 38 °C
Boiling point:: 282.4±35.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystals
pka: -6.82±0.10(Predicted)
color: Colourless
CAS DataBase Reference: 13600-42-5(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
RIDADR: 3439
HazardClass: TOXIC
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C978900
Product name: 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
Packaging: 10g
Price: $140
Updated: 2021/12/16

TRC

Product number: C978900
Product name: 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
Packaging: 25g
Price: $275
Updated: 2021/12/16

TRC

Product number: C978900
Product name: 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine
Packaging: 50g
Price: $495
Updated: 2021/12/16

Apolloscientific

Product number: PC2101D
Product name: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
Purity: 97%
Packaging: 1g
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-7-26
Product name: 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $21
Updated: 2021/12/16

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2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is used as a reagent in the synthesis of cyano(trifluoromethyl)aminopyridine derivatives which are used as androgen receptor antagonists for stimulating hair growth and reducing sebum production. 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is also used in the preparation of novel analogs of marine indole alkaloids which are used as potential anticancer agents.

Synthesis

3335-46-4

13600-42-5

GENERAL STEPS: In a 500 mL round bottom flask, 84.5 g (414 mmol) of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine, 400 g of phosphoryl chloride and 35 g of catalyst were added. The mixture was heated and refluxed for 20 h, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the reflux unit was changed to a distillation unit to evaporate the excess phosphorus trichloride. The reaction mixture was slowly poured into an ice-water mixture and a white solid was precipitated. The solid was collected by filtration and dried to give 79.6 g of the target product 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine in 79.78% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 475 - 477
[2] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0043; 0046-0047

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Suppliers

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View Lastest Price from 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-15

Career Henan Chemical Co

Product: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-30

13600-42-5, 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrileRelated Search:

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3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98%

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine

2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile

2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE

3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile

3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE

IFLAB-BB F2108-0099

BUTTPARK 43\57-39

2,6-Dichloro-4-(Trifluoromethy

3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine 98%

3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%

2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile

3-Pyridinecarbonitrile, 2,6-dichloro-4-(trifluoromethyl)-

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile ISO 9001：2015 REACH

,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

2,6-Dichloro-4-(trifluoromethyl)-3-pyridinecarbonitrile

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile?New

13600-42-5

C7HCl2F3N2

cyanide| alkyl chloride

Pyridine

Pyridine series

Pyridines