2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Product Name
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- CAS No.
- 445264-61-9
- Chemical Name
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Synonyms
- 2-(-2-Methoxypyridin-5-yl) Pyridine;2-Methoxypyridine-5-boronic acid pinacoL;6-Methoxy-pyridine-3-boronic acid picol ester;6-Methoxy-3-pyridylboronic Acid Pinacol Ester;2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER;2-methoxyl-5-pyridineboronic acid pinacol ester;6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER;(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester;2-Methoxypyridine-5-boronic acid pinacol ester 97%
- CBNumber
- CB9367724
- Molecular Formula
- C12H18BNO3
- Formula Weight
- 235.09
- MOL File
- 445264-61-9.mol
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Property
- Melting point:
- 47-51 °C(lit.)
- Boiling point:
- 102°C/0.08mmHg(lit.)
- Density
- 1.06±0.1 g/cm3(Predicted)
- Flash point:
- 216 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- pka
- 3.39±0.12(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 445264-61-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 636029
- Product name
- 2-Methoxypyridine-5-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $32
- Updated
- 2023/06/20
- Product number
- 636029
- Product name
- 2-Methoxypyridine-5-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $152
- Updated
- 2023/01/07
- Product number
- M2650
- Product name
- 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- M2650
- Product name
- 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- M267115
- Product name
- (2-Methoxypyridin-5-yl)boronicAcidPinacolEster
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Uses
(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.
Uses
2-Methoxypyridine-5-boronic acid pinacol ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.
Synthesis
13472-85-0
73183-34-3
445264-61-9
Step 1: 5-bromo-2-methoxypyridine (55 g, 0.29 mol), pinacol ester of bisboronic acid (90 g, 0.35 mol), potassium acetate (57 g, 0.58 mol) and bis(triphenylphosphine)palladium(II) chloride (2.2 g, 3 mmol) were dissolved in anhydrous dioxane (500 mL) under nitrogen protection. The reaction mixture was heated and stirred at 108 °C overnight. Upon completion of the reaction, the mixture was concentrated and purified by column chromatography using hexane/ethyl acetate as eluent to afford pinacol ester of 6-methoxypyridine-3-boronic acid (58 g, 84% yield).
References
[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 36
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 151
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 12, p. 2496 - 2500
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6477 - 6485
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Suppliers
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View Lastest Price from 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER manufacturers
- Product
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09