ChemicalBook > CAS DataBase List > (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE

(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE

Product Name: (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE
CAS No.: 51207-86-4
Chemical Name: (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE
Synonyms: AKOS B000462;N-(p-AMinoben;BUTTPARK 19\02-43;TIMTEC-BB SBB000456;ART-CHEM-BB B000462;CHEMBRDG-BB 3000462;p-AMinobenzoylMorpholine;4-(4-AMinobenzoyl)Morpholine;4-(p-AMinobenzoyl)Morpholine;4-AMINOBENZOIC ACID, MORPHOLIDE
CBNumber: CB9384325
Molecular Formula: C11H14N2O2
Formula Weight: 206.24
MOL File: 51207-86-4.mol

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(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE Property

Melting point:: 132-135°C
Boiling point:: 426.9±40.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.43±0.10(Predicted)
Appearance: Off-white to light brown Solid
CAS DataBase Reference: 51207-86-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A593790
Product name: p-Aminobenzoylmorpholine
Packaging: 10g
Price: $1320
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17693
Product name: 4-Aminobenzoylmorpholine
Packaging: 10g
Price: $1638
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17693
Product name: 4-Aminobenzoylmorpholine
Packaging: 5G
Price: $900.9
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015479
Product name: (4-AMINO PHENYL)(MORPHOLINO)METHANONE
Purity: 95.00%
Packaging: 2.5G
Price: $932.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17693
Product name: 4-Aminobenzoylmorpholine
Packaging: 2g
Price: $495.5
Updated: 2021/12/16

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(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE Chemical Properties,Usage,Production

Uses

(4-Amino-Phenyl)-Morpholin-4-yl-Methanone is an morpholine derivative used in the preparation of tyrosine kinase inhibitors and other biologically active agents.

Synthesis

5397-76-2

51207-86-4

Step - (ii): Synthesis of (4-aminophenyl)(morpholino)methanone: Intermediate-8a (8.5 g, 35.9 mmol) was dissolved in methanol (200 mL), 10% Pd/C (850 mg) was added and stirred for 4 hours at room temperature under H2 atmosphere. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and washed with excess methanol. The filtrate was concentrated in vacuum to afford the target product (7.0 g, 94.53%) as a light yellow solid.1H-NMR (400 MHz, DMSO-d6) δ: 7.12 (d, 2H, J = 8.4 Hz), 6.55 (d, 2H, J = 8.0 Hz), 5.5 (bs, 2H), 3.66-3.28 (m, 8H); MS (ES) m /z 207 (M + 1).

References

[1] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[2] Organic Letters, 2017, vol. 19, # 1, p. 194 - 197
[3] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529
[4] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 26; 27
[5] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 9, p. 1615 - 1620

(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE Suppliers

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51207-86-4, (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONERelated Search:

3-chloro-4-(morpholin-4-ylcarbonyl)aniline (4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE MORPHOLINO(4-NITROPHENYL)METHANONE (4-AMINO-PHENYL)-(2,6-DIMETHYL-MORPHOLIN-4-YL)-METHANONE (2-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE (3-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE 1-[4-(MORPHOLINOCARBONYL)PHENYL]-2-PYRROLIDINONE (3-([(4-CHLOROPHENYL)SULFONYL]METHYL)-4-NITROPHENYL)(MORPHOLINO)METHANONE 2-methyl-4-(morpholin-4-ylcarbonyl)aniline 2-methyl-4-[(2-methylmorpholin-4-yl)carbonyl]aniline 3-chloro-4-[(2-methylmorpholin-4-yl)carbonyl]aniline 2,4,6-TRINITROBENZOIC MORPHOLIDE 3-chloro-4-[(2,6-dimethylmorpholin-4-yl)carbonyl]aniline TOSLAB 21963 4-[(2-methylmorpholin-4-yl)carbonyl]aniline 4-[4-(4-(PYRAZIN-2-YL)-1H-PYRAZOL-1-YL)BENZOYL]MORPHOLINE Morpholine, 4-(4-((2-(2-chlorophenyl)-6-methyl-4-pyrimidinyl)amino)ben zoyl)-, monohydrochloride TOSLAB 863386

CHEMBRDG-BB 3000462

BUTTPARK 19\02-43

ART-CHEM-BB B000462

(4-AMINO-PHENYL)-MORPHOLIN-4-YL-METHANONE

(4-AMINOPHENYL)(MORPHOLINO)METHANONE

4-AMINOBENZOIC ACID, MORPHOLIDE

4-(MORPHOLIN-4-YLCARBONYL)PHENYLAMINE

AKOS B000462

TIMTEC-BB SBB000456

4-(morpholin-4-ylcarbonyl)aniline(SALTDATA: FREE)

p-AMinobenzoylMorpholine

4-(4-Aminobenzoyl)morpholine Other Name (4-Aminophenyl)(4-morpholinyl)methanone

1-(4-AMinophenyl)-1-Morpholin-4-ylMethanone

4-(4-AMinobenzoyl)Morpholine

4-(4-Morpholinylcarbonyl)aniline

4-(p-AMinobenzoyl)Morpholine

N-(p-AMinoben

Methanone, (4-aminophenyl)(4-morpholyl)-

Morpholine, 4-(4-aminobenzoyl)-

4-(morpholine-4-carbonyl)aniline

Methanone, (4-aminophenyl)-4-morpholinyl-

51207-86-4

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