ChemicalBook > CAS DataBase List > 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

Product Name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
CAS No.
306936-57-2
Chemical Name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
Synonyms
AKOS B000254;AKOS PAO-0297;ART-CHEM-BB B000254;CHEMBRDG-BB 4301174;3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE;3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde;3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde;3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde;Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
CBNumber
CB9396160
Molecular Formula
C10H7FN2O
Formula Weight
190.17
MOL File
306936-57-2.mol
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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Property

Melting point:
160 °C
Boiling point:
416.0±35.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
form 
powder to crystal
pka
10.69±0.50(Predicted)
color 
White to Orange to Green
Sensitive 
Air Sensitive
InChI
1S/C10H7FN2O/c11-9-3-1-7(2-4-9)10-8(6-14)5-12-13-10/h1-6H,(H,12,13)
InChIKey
CMXTUUXWJBLVEH-UHFFFAOYSA-N
SMILES
Fc1ccc(cc1)-c2n[nH]cc2C=O
CAS DataBase Reference
306936-57-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29331990
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
683272
Product name
3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
Purity
97%
Packaging
1g
Price
$85
Updated
2023/06/20
TCI Chemical
Product number
F1118
Product name
3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$108
Updated
2025/07/31
TCI Chemical
Product number
F1118
Product name
3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$328
Updated
2025/07/31
Frontier Specialty Chemicals
Product number
JK250171
Product name
3-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde
Purity
97%
Packaging
1g
Price
$116
Updated
2021/12/16
Apolloscientific
Product number
PC6717
Product name
3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
Purity
97%
Packaging
5g
Price
$117
Updated
2021/12/16
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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow-orange solid

Synthesis

326-33-0

68-12-2

306936-57-2

General procedure for the synthesis of 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde from 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide and N,N-dimethylformamide: Phosphorochloride (2.1 mL, 23 mmol) was slowly added dropwise to N,N-dimethylformamide (4.4 mL, 57 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 30 min. Subsequently, the reaction mixture was cooled in an ice/water bath and 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide (1.96 g, 10 mmol) was slowly added, controlling the temperature not to exceed 50 °C. After the addition was completed, the reaction system was heated to 80 °C and stirred at this temperature for 2 hours. After completion of the reaction, the mixture was poured into ice (15 g) and the pH was adjusted to 10 with 5N NaOH solution and stirred for 2 hours. Subsequently, the reaction solution was acidified with concentrated hydrochloric acid and stirring was continued for 4 hours. The precipitated solid was collected by filtration, washed with a small amount of water and dried under high vacuum to give the target product 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde (1.5 g, 79% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 4932 - 4935
[2] Russian Journal of General Chemistry, 2005, vol. 75, # 5, p. 782 - 789
[3] Patent: WO2013/22766, 2013, A1. Location in patent: Page/Page column 87
[4] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 36 - 49
[5] Journal of Fluorine Chemistry, 2016, vol. 183, p. 59 - 68

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Sodium acetate Ethanol N,N-Dimethylformamide Phosphorus oxitrichloride 4-Fluoroacetophenone Semicarbazide hydrochloride

Preparation Products

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3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Suppliers

Americas 1 Belgium 1 China 67 Europe 1 Germany 4 India 6 Japan 1 Russia 2 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 17 Global 110
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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China
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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Energy Chemical
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Nanjing Habo Medical Technology Co., Ltd.
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025-85760892 13376080562
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sales@habotech.com
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Thermo Fisher Scientific
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cnchemical@thermofisher.com
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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03-3668-0520
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Sales-JP@TCIchemicals.com
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Japan
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TCI Europe
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320-37350700
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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+1-888-520-1075 / +1-503-283-1987
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View Lastest Price from 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers

Career Henan Chemical Co
Product
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 306936-57-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

306936-57-2, 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDERelated Search:

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1H-Pyrazole-4-carboxaldehyde 3-(4-FLUOROPHENYL)-1-P-TOLYL-1H-PYRAZOLE-4-CARBALDEHYDE RARECHEM AL BF 1274 1-(4-BROMOPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-(4-FLUORO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-(4-FLUORO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-[3-(4-FLUOROPHENYL)-4-FORMYL-1H-PYRAZOL-1-YL]PROPANENITRILE 1,3-BIS(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(3-CHLORO-4-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE RARECHEM AL BO 2161 5-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-[3-(3,4-DIFLUOROPHENYL)-4-FORMYL-1H-PYRAZOL-1-YL]PROPANENITRILE 1-(4-CHLOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(3-CHLOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(2,4-DIFLUOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

  • AKOS B000254
  • AKOS PAO-0297
  • 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
  • 3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE
  • CHEMBRDG-BB 4301174
  • ART-CHEM-BB B000254
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde 97%
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde97%
  • 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)
  • Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde ,97%
  • 5-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
  • 3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde
  • 3-(4-fluorophenyl)-2H-pyrazole-4-carboxaldehyde
  • JR-8855, 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde, 97%
  • 3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde
  • 1H-Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
  • 3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde
  • 3-(4-FLOURO PHENYLE) -1H-PYRAZOLE -4-CARBOXALDEHYDE
  • 3-(4-Fluorophenyl)-1<i>H</i>-pyrazole-4-carboxaldehyde
  • 306936-57-2
  • New Products for Chemical Synthesis May/June 2007
  • Building Blocks
  • C10
  • C10-C12
  • Carbonyl Compounds
  • Chemical Synthesis
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  • Pyrazoles & Triazoles
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  • Pyrazoles