Tibolone

Product Name: Tibolone
CAS No.: 5630-53-5
Chemical Name: Tibolone
Synonyms: LIVIAL;Tiblone;LIVIELLA;TIBOLONE;Tiboione;tibolona;Org OD 14;tibolonum;Tibolone(EP);Tibolone IMpurity
CBNumber: CB9453050
Molecular Formula: C21H28O2
Formula Weight: 312.45
MOL File: 5630-53-5.mol

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Tibolone Property

Melting point:: 169 °C
Boiling point:: 447.4±45.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
refractive index: 105 ° (C=0.54, CH2Cl2/Et2O)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 13.10±0.60(Predicted)
color: white to beige
Merck: 9427
InChI: InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3
InChIKey: WZDGZWOAQTVYBX-PGFZCDQENA-N
SMILES: [C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r|
CAS DataBase Reference: 5630-53-5(CAS DataBase Reference)

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Safety

Hazard Codes: N
Risk Statements: 51/53
Safety Statements: 22-24/25-61
RIDADR: UN 3077 9/PG 3
RTECS: RC8964020

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000668
Product name: Tibolone for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000668
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 10006321
Product name: Tibolone
Purity: ≥98%
Packaging: 100mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 10006321
Product name: Tibolone
Purity: ≥98%
Packaging: 250 mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 10006321
Product name: Tibolone
Purity: ≥98%
Packaging: 500mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 10006321
Product name: Tibolone
Purity: ≥98%
Packaging: 1 g
Price: $287
Updated: 2024/03/01

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Tibolone Chemical Properties,Usage,Production

Description

Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.

Chemical Properties

White Solid

Originator

Akzo (Organon) (The Netherklands)

Uses

A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome

Definition

ChEBI: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormon receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.

brand name

Livial

Pharmacokinetics

Raloxifene is rapidly absorbed following oral administration, with an estimated 60% absorption, but it has a very low bioavailability (2%), associated with extensive phase II metabolism. The metabolites are excreted via the bile, with potential enterohepatic recycling that could account for the interaction with cholestyramine. Supportive of the enterohepatic recycling is the half-life of 28 hours. Metabolism of raloxifene occurs to a great extent in the intestine and consists of glucuronide conjugation catalyzed by uridine diphosphate glucuronosyltransferase (UGT).

Clinical Use

Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.

Side effects

The most common reason for patient withdrawal from clinical trials was vaginal bleeding (also a common side effect when estrogen therapy is used).

Tibolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tibolone Suppliers

Canada 1 China 147 India 10 Italy 2 Malaysia 1 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 14 Global 183

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 2002
Advantage: 62

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3429
Advantage: 58

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View Lastest Price from Tibolone manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: Tibolone 5630-53-5
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2024-01-18

Nantong Guangyuan Chemicl Co,Ltd

Product: Tibolone 5630-53-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-01

Nantong Guangyuan Chemicl Co,Ltd

Product: Tibolone 5630-53-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-12-07

5630-53-5, TiboloneRelated Search:

chlorempenthrin Thiophanate-methyl Kresoxim-methyl Methyl acrylate Methylparaben Allyl methacrylate 6-Methyl-5-hepten-2-one Empenthrin Bensulfuron methyl 3-Methyl butynol METHYL THIOPHENE-2-CARBOXYLATE Methyl cyclopentenolone METHYLCYCLOPENTADIENE DIMER CHLOROPHOSPHONAZO III Methyl 1-ETHYNYLCYCLOPENTANOL Parathion-methyl NORETHYNODREL

TIBOLONE

LIVIELLA

LIVIAL

5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE

(7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE

17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one

17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE

19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)-

17β-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-ene-20-yn-3-one

(7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one

7a-Methyl-17a-ethynyl-17-hydroxy-5(10)-estren-3-one

7a-Methyl-5,10-norethindrone

Org OD 14

(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one

19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)-

7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one

7a-Methyl-D5,10-norethindrone

Tibolone 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one

17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one

5(10)-Estren-7α-methyl-17α- ethynyl-17β- ol-3-one

Tiboione

Tibolone(EP)

7α-Methyl-17α-ethynyl-17β-hydroxy-5(10)-estren-3-one

7α-Methyl-5,10-norethindrone

(7R,13S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

(7R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

Tiblone

Tibolone for system suitability CRS

tibolona

tibolonum

19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-

(7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Tibolone USP/EP/BP

Tibolone D5Q: What is Tibolone D5 Q: What is the CAS Number of Tibolone D5 Q: What is the storage condition of Tibolone D5 Q: What are the applications of Tibolone D5

TiboloneQ: What is Tibolone Q: What is the CAS Number of Tibolone Q: What is the storage condition of Tibolone Q: What are the applications of Tibolone

5(10)-ESTREN-7α-METHYL-17α- ETHYNYL-17β- OL-3-ONE

Tibolone IMpurity

Tibolone (Liviella) (Livial)

5630-53-5

5630-53-6

Steroid and Hormone

Active Pharmaceutical Ingredients

Hormone

Acetylenes

Biochemistry

Functionalized Acetylenes

Hydroxyketosteroids

Steroids

Intermediates & Fine Chemicals

Pharmaceuticals