Methyllycaconitine (citrate)
- Product Name
- Methyllycaconitine (citrate)
- CAS No.
- 351344-10-0
- Chemical Name
- Methyllycaconitine (citrate)
- Synonyms
- (10S)-Methyllycaconitine citrate;Methyllycaconitine citrate, 10 mM in DMSO
- CBNumber
- CB94666704
- Molecular Formula
- C43H58N2O17
- Formula Weight
- 874.93
- MOL File
- 351344-10-0.mol
Methyllycaconitine (citrate) Property
- storage temp.
- Desiccate at -20°C
- solubility
- Water: Soluble
- form
- A solid
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- 21398
- Product name
- Methyllycaconitine (citrate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 21398
- Product name
- Methyllycaconitine (citrate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 21398
- Product name
- Methyllycaconitine (citrate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 21398
- Product name
- Methyllycaconitine (citrate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $288
- Updated
- 2024/03/01
- Product number
- CS-0021211
- Product name
- Methyllycaconitinecitrate
- Purity
- 98.55%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
Methyllycaconitine (citrate) Chemical Properties,Usage,Production
Description
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM). It is less effective at other nAChRs. MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Uses
Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR) with blood-brain barrier permeability.
in vivo
Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group)[1].
storage
Store at -20°C
References
[1] Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014 Oct 31;9(10):e111536. DOI:10.1371/journal.pone.0111536
[2] Escubedo E, et al. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther. 2005 Nov;315(2):658-67. DOI:10.1124/jpet.105.089748
[3] Lockman PR, et al. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. J Neurochem. 2005 Jul;94(1):37-44. DOI:10.1111/j.1471-4159.2005.03162.x
Methyllycaconitine (citrate) Preparation Products And Raw materials
Raw materials
Preparation Products
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