2-AMINO CYCLOPENTANOL

2-AMINO CYCLOPENTANOL Property

Boiling point:

114-115℃ (13 Torr)

Density 

1.0617 g/cm3(Temp: 15 °C)

refractive index 

1.4965 (589.3 nm 15℃)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.93±0.40(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

89381-13-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

RIDADR 

UN3082

HazardClass 

9

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

2-AMINO CYCLOPENTANOL Chemical Properties,Usage,Production

Uses

2-Aminocyclopentanol can be used as a pharmaceutical synthesis intermediate. It can be prepared from cyclopentane oxide as a reaction raw material. It can be used to prepare 5-methyl-2-(pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one compounds. It can also be used to prepare drugs for treating diseases related to cyclin-dependent kinase signaling pathways.

Synthesis

General procedure for the synthesis of (1S,2S)-2-aminocyclopentanol from the compound (CAS:672310-36-0): 0.900 g (3.82 mmol) of (S,S)-2-benzyloxycarbonylaminocyclopentanol and 0.36 g of 5% palladium-carbon catalyst were added to the reaction system in a 50 mL autoclave. Under nitrogen protection, 4.5 mL of degassed methanol was added to the reaction system. The reaction mixture was stirred at 50 °C for 3 hours under hydrogen pressure of 2 MPa. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated by rotary evaporator to give 0.59 g of crude product. The product was determined to have an enantiomeric excess (ee) percentage of more than 99%. The 1H-NMR (200 MHz, CDCl3) data of the product were as follows: δ 1.2-1.3 (m, 1H), 1.5 (m, 1H), 1.6-1.7 (m, 2H), 1.9-2.0 (m, 2H), 2.3-2.5 (br, 3H), 3.0 (m, 1H), 3.7 (m, 1H).

References

[1] Patent: EP1398310, 2004, A1. Location in patent: Page 16-17