(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&

Product Name: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
CAS No.: 133812-16-5
Chemical Name: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
Synonyms: Locostatin;(E/Z)-Locostatin;4-benzyl-3-crotonyl-2-oxazolidinone;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;Cell Sheet Migration Inhibitor, Locostatin;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-
CBNumber: CB9499650
Molecular Formula: C14H15NO3
Formula Weight: 245.27
MOL File: 133812-16-5.mol

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(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Property

Melting point:: 84-88 °C(lit.)
Boiling point:: 351.0±25.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (60 mg/ml)
form: solid
pka: -1?+-.0.40(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64425
Product name: Locostatin
Packaging: 10mg
Price: $128.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64425
Product name: Locostatin
Packaging: 50mg
Price: $390.65
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 100mg
Price: $595
Updated: 2024/03/01

Cayman Chemical

Product number: 29092
Product name: (E/Z)-Locostatin
Packaging: 5mg
Price: $62
Updated: 2024/03/01

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(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties,Usage,Production

Description

Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5

Uses

Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration

References

Zhu et al. (2005), A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration; Chem. Biol., 12 981 Beshir et al. (2011), Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket; For. Immunopathol. Dis. Therap. 2 47 Menoret et al. (2009), The oxazolidinone derivative locostatin induces cytokine appeasement; J. Immunol. 183 7489 Ma et al. (2019), Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice; Dig. Dis. Sci. 64 2570 Mc Henry et al. (2008), Raf kinase inhibitor protein positively regulates cell-cell adhesion; J. Cell Biochem. 103 972

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& manufacturers

Career Henan Chemical Co

Product: (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& 133812-16-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

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(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&

4-benzyl-3-crotonyl-2-oxazolidinone

Locostatin

(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%

(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one

Cell Sheet Migration Inhibitor, Locostatin

(E/Z)-Locostatin

2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-

133812-16-5

S4Benzyl3crotonyl2oxazolidinone97