(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- Product Name
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- CAS No.
- 133812-16-5
- Chemical Name
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&
- Synonyms
- Locostatin;(E/Z)-Locostatin;4-benzyl-3-crotonyl-2-oxazolidinone;(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI&;Cell Sheet Migration Inhibitor, Locostatin;(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one;(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one, 98%;2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)-
- CBNumber
- CB9499650
- Molecular Formula
- C14H15NO3
- Formula Weight
- 245.27
- MOL File
- 133812-16-5.mol
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Property
- Melting point:
- 84-88 °C(lit.)
- Boiling point:
- 351.0±25.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (60 mg/ml)
- form
- solid
- pka
- -1?+-.0.40(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J64425
- Product name
- Locostatin
- Packaging
- 10mg
- Price
- $128.65
- Updated
- 2024/03/01
- Product number
- J64425
- Product name
- Locostatin
- Packaging
- 50mg
- Price
- $390.65
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 10mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 100mg
- Price
- $595
- Updated
- 2024/03/01
- Product number
- 29092
- Product name
- (E/Z)-Locostatin
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Chemical Properties,Usage,Production
Description
Locostatin (133812-16-5) inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3? Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Uses
Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration
References
Zhu et al. (2005), A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration; Chem. Biol., 12 981 Beshir et al. (2011), Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket; For. Immunopathol. Dis. Therap. 2 47 Menoret et al. (2009), The oxazolidinone derivative locostatin induces cytokine appeasement; J. Immunol. 183 7489 Ma et al. (2019), Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice; Dig. Dis. Sci. 64 2570 Mc Henry et al. (2008), Raf kinase inhibitor protein positively regulates cell-cell adhesion; J. Cell Biochem. 103 972
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& manufacturers
- Product
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDI& 133812-16-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01