(S)-1-BOC-3-ACETAMIDOPYRROLIDINE

Product Name: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE
CAS No.: 114636-37-2
Chemical Name: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE
Synonyms: (S)-N-Boc-3-acetamidopyrrolidine;(S)-1-BOC-3-ACETYLAMINO PYRROLIDINE;(S)-(-)-1-BOC-3-ACETAMIDOPYRROLIDINE;(S)-N-Boc-3-acetamidopyrrolidine,99%e.e.;(S)-(?)-1-Boc-3-acetamidopyrrolidine;tert-Butyl (S)-3-acetamidopyrrolidine-1-carboxylate;(S)-tert-Butyl 3-acetaMidopyrrolidine-1-carboxylate;tert-butyl (3s)-3-acetamidopyrrolidine-1-carboxylate;TERT-BUTYL (3S)-3-(ACETYLAMINO)-1-PYRROLIDINECARBOXYLATE;1-Pyrrolidinecarboxylic acid, 3-(acetylamino)-, 1,1-dimethylethyl ester, (3S)-
CBNumber: CB9500381
Molecular Formula: C11H20N2O3
Formula Weight: 228.29
MOL File: 114636-37-2.mol

More

Less

(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Property

Melting point:: 86-90 °C
Boiling point:: 381.3±31.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.83±0.20(Predicted)
form: solid
optical activity: [α]20/D -18°, c = 3.5 in methanol

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 2

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 665088
Product name: (S)-(?)-1-Boc-3-acetamidopyrrolidine
Purity: 97%
Packaging: 5g
Price: $778
Updated: 2023/06/20

Sigma-Aldrich

Product number: 665088
Product name: (S)-(?)-1-Boc-3-acetamidopyrrolidine
Purity: 97%
Packaging: 1g
Price: $171
Updated: 2023/01/07

AK Scientific

Product number: Z2166
Product name: (S)-tert-Butyl3-acetamidopyrrolidine-1-carboxylate
Packaging: 5g
Price: $226
Updated: 2021/12/16

Activate Scientific

Product number: AS42494
Product name: 1-Boc-(S)-3-(acetamido)pyrrolidine
Purity: 97% ee
Packaging: 25g
Price: $783
Updated: 2021/12/16

AK Scientific

Product number: Z2166
Product name: (S)-tert-Butyl3-acetamidopyrrolidine-1-carboxylate
Packaging: 25g
Price: $838
Updated: 2021/12/16

More

Less

(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Chemical Properties,Usage,Production

Synthesis

108-24-7

147081-44-5

114636-37-2

Step 1: (S)-1-Boc-3-aminopyrrolidine (930 mg, 5 mmol) was dissolved in anhydrous dichloromethane (50 mL) and cooled to 0 °C. Subsequently, triethylamine (1.4 mL, 10 mmol) and acetic anhydride (567 μL, 6 mmol) were added sequentially. The reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (20 mL) and the organic layer was separated. The aqueous layer was extracted twice with dichloromethane (10 mL × 2). The combined organic layers were washed with brine (30 mL), dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography to afford the target product S-1-Boc-3-N-acetylpyrrolidine (0.69 g, 60% yield).1H NMR (CDCl3, 400 MHz): δ 6.36-6.06 (br s, 1H), 4.45-4.36 (m, 1H), 3.68-3.48 (m, 1H), 3.43- 3.30 (m, 2H), 3.24-3.08 (m, 1H), 2.14-2.04 (m, 1H), 1.95 (s, 3H), 1.90-1.73 (m, 1H), 1.42 (s, 9H).

References

[1] Patent: WO2011/160020, 2011, A2. Location in patent: Page/Page column 68
[2] Patent: WO2006/64336, 2006, A2. Location in patent: Page/Page column 33

(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(S)-1-BOC-3-ACETAMIDOPYRROLIDINE Suppliers

China 37 Germany 1 Switzerland 2 United Kingdom 1 United States 7 Global 48

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Greenherbs Science and Technology Development Co., Ltd.

Tel: 010-61136123
Fax: +86 (10) 8857-9127
Email: pub02@greenherbs.com.cn
Country: China
ProdList: 4049
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Shanghai Jianchao Biotechnology Co., LTD

Tel: 15021035486 18081542813
Email: 1804873256@qq.com
Country: China
ProdList: 6684
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Jining Yize Pharmaceutical Technology Co., Ltd

Tel: 15192473210
Email: 302633902@qq.com
Country: China
ProdList: 4480
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

ZhengZhou Edward Biology Co.,Ltd

Tel: 13298105281
Email: 1522334715@qq.com
Country: China
ProdList: 7507
Advantage: 58

Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.

Tel: 028-85755578 18140172005
Email: 33544634@qq.com
Country: China
ProdList: 691
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

DAMING CHANGDA CO.,LTD

Tel: --
Fax: --
Email: joelee@changdapharm.com
Country: China
ProdList: 5640
Advantage: 30

DSL Chemicals Co.，Ltd

Tel: --
Fax: --
Email: info@DSLChem.com
Country: China
ProdList: 6983
Advantage: 65

114636-37-2, (S)-1-BOC-3-ACETAMIDOPYRROLIDINERelated Search:

3-ACETAMIDOPYRROLIDINE (S)-1-BOC-3-ACETAMIDOPYRROLIDINE 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI) Phosphonium,[(3'S)-1'-[(1,1-dimethylethoxy)carbonyl]-2-oxo[1,3'-bipyrrolidin]-3-yl]triphenyl-,bromide (3S)-(-)-3-ACETAMIDOPYRROLIDINE

(S)-(-)-1-BOC-3-ACETAMIDOPYRROLIDINE

(S)-1-BOC-3-ACETYLAMINO PYRROLIDINE

TERT-BUTYL (3S)-3-(ACETYLAMINO)-1-PYRROLIDINECARBOXYLATE

(S)-tert-Butyl 3-acetaMidopyrrolidine-1-carboxylate

tert-Butyl (S)-3-acetamidopyrrolidine-1-carboxylate

(S)-N-Boc-3-acetamidopyrrolidine,99%e.e.

tert-butyl (3s)-3-acetamidopyrrolidine-1-carboxylate

(S)-N-Boc-3-acetamidopyrrolidine

1-Pyrrolidinecarboxylic acid, 3-(acetylamino)-, 1,1-dimethylethyl ester, (3S)-

(<i>S</i>)-(?)-1-Boc-3-acetamidopyrrolidine

114636-37-2