DIGOXIGENIN NHS-ESTER

DIGOXIGENIN NHS-ESTER Property

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: soluble

form 

powder

pka

14.43±0.70(Predicted)

color 

White to off-white

Stability:

Moisture Sensitive

InChIKey

KHNDABJZSPPYLE-BPYGFDTQNA-N

Safety

Hazard Codes 

T+

Risk Statements 

26/27/28-33

Safety Statements 

28-36/37-45

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

H331Toxic if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

DIGOXIGENIN NHS-ESTER Chemical Properties,Usage,Production

Uses

Digoxigenin NHS-ester is an activated ester which reacts with amino groups under mild conditions, attaching the digoxigenin moiety to proteins or 5′-amino substituted oligonucleotides Digoxigenin labeling is used to immuno-tag molecules for detection using anti-digoxigenin antibodies with high affinities and specificity.

Uses

Digoxigenin-3-O-methylcarbonyl-ε-aminocaproic acid-N-hydroxysuccinimide ester has been used to label the sequence (III) for the linker molecule sequence (VIII).

General Description

Chemical reagent for the labeling of proteins and oligonucleotides. One reactive group is able to interact with NH₂-groups (of proteins or oligonucleotides), another reactive group (Digoxigenin) reacts with Anti-Digoxigenin and thus can be detected.

Biochem/physiol Actions

Digoxigenin, a non-radioactive immune-tag is mainly used for labeling proteins and in situ?hybridization.