J-14

Product Name: J-14
CAS No.: 1043854-13-2
Chemical Name: J-14
Synonyms: J14, 10 mM in DMSO;4-(((4-(4-(2-Chlorophenyl)piperazin-1-yl)-6-phenylpyrimidin-2-yl)thio)methyl)benzoic acid;Benzoic acid, 4-[[[4-[4-(2-chlorophenyl)-1-piperazinyl]-6-phenyl-2-pyrimidinyl]thio]methyl]-;4-[({4-[4-(2-chlorophenyl)piperazin-1-yl]-6-phenylpyrimidin-2-yl}sulfanyl)methyl]benzoic acid;cancer,inhibit,damage,Sulfiredoxin,J14,cytotoxicity,Reactive Oxygen Species,J 14,death,adenocarcinoma,Inhibitor,lung,mitochondrial,cells
CBNumber: CB95559036
Molecular Formula: C28H25ClN4O2S
Formula Weight: 517.04
MOL File: 1043854-13-2.mol

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J-14 Property

Boiling point:: 762.9±60.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 260 mg/mL (502.86 mM)
pka: 4.08±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0109037
Product name: J14
Purity: 99.45%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0109037
Product name: J14
Purity: 99.45%
Packaging: 50mg
Price: $295
Updated: 2021/12/16

ChemScene

Product number: CS-0109037
Product name: J14
Purity: 99.45%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0109037
Product name: J14
Purity: 99.45%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0109037
Product name: J14
Purity: 99.45%
Packaging: 25mg
Price: $195
Updated: 2021/12/16

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J-14 Chemical Properties,Usage,Production

Uses

J14 is a reversible sulfiredoxin inhibitor with an IC50 of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death[1].

Biological Activity

J14 is a reversible sulfiredoxin inhibitor with IC50 of 8.1 μM. J14 induces oxidative stress (leading to intracellular ROS accumulation) by inhibiting sulfiredoxin, which leads to cytotoxicity and cancer cell death.

in vitro

J14 (0-100 μM; 0-96 hours; A549 cells) treatment inhibits the growth of A549 cells in a concentration- and a time-dependent manner, and its half inhibitory concentration for the growth of A549 cells was 15.7 μM.
J14 (20 μM; 48-72 hours; A549 cells) treatment causes not only the release of cytochrome c into the cytosol, but also the activation of caspase-3 and caspase-9. J14 induces oxidative damage to mitochondria, resulting in caspase-mediated apoptosis.
J14 treatment significantly increases the accumulation of sulfinic peroxiredoxins and intracellular ROS. Excess accumulation of intracellular ROS causes oxidative damage, leading to cell death. J14 significantly induces cell death in A549 cells in a time-dependent manner, resulting in approximately 40% cell death in 96 hours.
J14 induces oxidative mitochondrial damage and apoptosis.

Cell Viability Assay

Cell Line:	A549 cells
Concentration:	0-100 μM
Incubation Time: < /td>	0 hour, 24 hours, 48 hours, 72 hours, 96 hours
Result:	Inhibited the growth of A549 cells in a concentration- and a time- dependent manner.

Western Blot Analysis

< /tr>

Cell Line:	A549 cells
Concentration:	20 μM
Incubation Time:	48 hours, 72 hours
Result:	Caused not only the release of cytochrome c into the cytosol, but also the activation of caspase -3 and caspase-9.

in vivo

J14 (50 mg/kg; intraperitoneal injection; daily; for 16 days; BALB/c nude female mice) treatment significantly reduces the average tumor volume. The masses and weights of the primary tumors excised from the J14-

Animal Model:	Six-week-old BALB/c nude female mice injected with A549 cells
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; daily; for 16 days
Result:	Significantly reduced the growth of human lung tumor without acute toxicity.

target

IC50: 8.1 μM (Sulfiredoxin); ROS

References

[1] Kim H, et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74. DOI:10.1016/j.freeradbiomed.2015.12.023

J-14 Preparation Products And Raw materials

Raw materials

Preparation Products

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J-14 Suppliers

China 32 United States 4 Global 36

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1043854-13-2, J-14Related Search:

Benzoic acid, 4-[[[4-[4-(2-chlorophenyl)-1-piperazinyl]-6-phenyl-2-pyrimidinyl]thio]methyl]-

4-(((4-(4-(2-Chlorophenyl)piperazin-1-yl)-6-phenylpyrimidin-2-yl)thio)methyl)benzoic acid

cancer,inhibit,damage,Sulfiredoxin,J14,cytotoxicity,Reactive Oxygen Species,J 14,death,adenocarcinoma,Inhibitor,lung,mitochondrial,cells

4-[({4-[4-(2-chlorophenyl)piperazin-1-yl]-6-phenylpyrimidin-2-yl}sulfanyl)methyl]benzoic acid

J14, 10 mM in DMSO

1043854-13-2

C28H25ClN4O2S