ChemicalBook > CAS DataBase List > Methyl 2-(chlorosulfonyl)benzoate

Methyl 2-(chlorosulfonyl)benzoate

Product Name: Methyl 2-(chlorosulfonyl)benzoate
CAS No.: 26638-43-7
Chemical Name: Methyl 2-(chlorosulfonyl)benzoate
Synonyms: CBC;thyl 2-(chlorosulfon;Methly 2-chlorosulfonylbenzoate;2-Chlorosulfonyl methyl benzoate;Methyl 2-(chorosulfonyl)benzoate;METHYL 2-(CHLOROSULFONYL)BENZOATE;METHYL-O-(CHLOROSULFONYL)BENZOATE;Methyl 2-(chlorosulphonyl)benzoate;Methyl 2-(chlorosulfonyl)benzoateCBC;O-CARBOMETHOXYBENZENESULFONYLCHLORIDE
CBNumber: CB9665499
Molecular Formula: C8H7ClO4S
Formula Weight: 234.66
MOL File: 26638-43-7.mol

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Methyl 2-(chlorosulfonyl)benzoate Property

Melting point:: 62-63 °C
Boiling point:: 344.8±25.0 °C(Predicted)
Density: 1.4452 (estimate)
storage temp.: Inert atmosphere,2-8°C
form: Crystalline Powder or Chunks
color: White to beige or pink
Water Solubility: reacts
Sensitive: Moisture Sensitive
InChI: InChI=1S/C8H7ClO4S/c1-13-8(10)6-4-2-3-5-7(6)14(9,11)12/h2-5H,1H3
InChIKey: HUNUAFNLLYVTQD-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=CC=C1S(Cl)(=O)=O
CAS DataBase Reference: 26638-43-7(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 2-(chlorosulfonyl)-, methyl ester (26638-43-7)

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Safety

Hazard Codes: C
Risk Statements: 34-29-14
Safety Statements: 45-36/37/39-30-26-22
RIDADR: 3261
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: M220563
Product name: Methyl2-(Chlorosulfonyl)benzoate
Packaging: 5mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6662-5-Y8
Product name: Methyl 2-(chlorosulfonyl)benzoate
Packaging: 5G
Price: $64
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK187762
Product name: Methyl2-(chlorosulfonyl)benzoate
Purity: 95%
Packaging: 5g
Price: $66
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC12436
Product name: 2-Chlorosulfonyl methyl benzoate
Packaging: 5G
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: W4991
Product name: Methyl2-(chlorosulfonyl)benzoate
Packaging: 10g
Price: $97
Updated: 2021/12/16

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Methyl 2-(chlorosulfonyl)benzoate Chemical Properties,Usage,Production

Chemical Properties

white to beige or pink crystalline powder

Uses

Methyl 2-(chlorosulfonyl)benzoate can be used as intermediates in pharmaceuticals, saccharin, dyes, & pigments.

Synthesis Reference(s)

Synthesis, p. 1203, 1992 DOI: 10.1055/s-1992-26333

Synthesis

134-20-3

26638-43-7

2-Methoxycarbonylbenzenesulfonyl chloride was synthesized by a continuous flow reaction system using methyl o-aminobenzoate as starting material. The system configuration consisted of two tubular reactors: the first reactor (20 m long, 15 mm diameter) and the second reactor (40 m long, 10 mm diameter, filled with 3 mm diameter copper spheres). The reaction materials included 1587 g of methyl o-aminobenzoate (35 wt% hydrochloric acid solution containing 1916 g of hydrogen chloride), 6720 g of 30 wt% sodium nitrite solution (containing 2016 g of sodium nitrite), 6825 g of saturated sodium bisulfite solution (containing 2730 g of sodium bisulfite), and 7936 g of methylene chloride. The operating steps are as follows: 1. the first tubular reactor was maintained at 80 °C through a heat exchanger, and 20 wt% hydrochloric acid, 40 wt% sodium nitrite solution, and methyl o-aminobenzoate were continuously transported by three metering pumps at a flow rate ratio of 1:5:3, respectively, to the first mixer, and after mixing, they were fed into the first reactor for diazotization reaction with a residence time of 100 s. The reaction solution was collected in the fourth storage tank. 2. the saturated sodium bisulfite solution and methylene chloride are stored in the fifth storage tank, respectively, and transported to the second mixer through the fourth and fifth metering pumps with the diazotization reaction solution in the ratio of methyl o-aminobenzoate to sodium bisulfite molar ratio of 1:2.5, and the ratio of flow rate of methyl o-aminobenzoate to methylene chloride flow rate of 1:5. 3. the mixed solution was reacted in the second reactor at 100°C for a residence time of 90 seconds. 4. Upon completion of the reaction, the reaction solution was collected for 2 minutes (equivalent to an amount of 624 g of methyl phthalate), transferred to a receiver tank for layering, separation of the organic layer, evaporation of methylene chloride and drying to give 910 g of 2-methoxycarbonylbenzenesulfonyl chloride in 94% yield.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 12, p. 2116 - 2123
[2] Patent: CN105732441, 2016, A. Location in patent: Paragraph 0041; 0042
[3] Patent: CN105949091, 2016, A. Location in patent: Paragraph 0030

Methyl 2-(chlorosulfonyl)benzoate Preparation Products And Raw materials

Raw materials

Methyl anthranilate Copper(II) chloride dihydrate Sodium chloride Sodium sulfite Sulfur dioxide 2-Aminobiphenyl Dark green Sodium nitrite Copper(I) chloride Hydrochloric acid Sodium bicarbonate Dichloromethane Acetic acid Methanol Anthranilic acid Sulfuric acid

Preparation Products

Saccharin sodium dihydrate Saccharin SACCHARIN SODIUM SALT DIHYDRATE

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View Lastest Price from Methyl 2-(chlorosulfonyl)benzoate manufacturers

Career Henan Chemical Co

Product: Methyl 2-(chlorosulfonyl)benzoate 26638-43-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-01-29

26638-43-7, Methyl 2-(chlorosulfonyl)benzoateRelated Search:

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Benzoic acid, 2-(chlorosulfonyl)-, methyl ester

o-(Methoxycarbonyl)benzenesulphonyl chloride

Methyl 2-(chlorosulfonyl)benzoate, 90%, tech.

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METHYL 2-(CHLOROSULFONYL)BENZOATE

CBC

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O-CARBOMETHOXYBENZENESULFONYLCHLORIDE

26638-43-7

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