ChemicalBook > CAS DataBase List > 4-Aminophthalimide

4-Aminophthalimide

Product Name
4-Aminophthalimide
CAS No.
3676-85-5
Chemical Name
4-Aminophthalimide
Synonyms
RMA-93;AKOS 92231;Roxadustat-003;4-AMINOPHTHALIMIDE;4-Amino-phthalamide;5-AMINO PHTHALIMIDE;TIMTEC-BB SBB001589;Phthalimide, 4-amino-;OTAVA-BB BB0111070393;SPECS AE-641/30105046
CBNumber
CB9671267
Molecular Formula
C8H6N2O2
Formula Weight
162.15
MOL File
3676-85-5.mol
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4-Aminophthalimide Property

Melting point:
290 °C
Boiling point:
288.82°C (rough estimate)
Density 
1.3264 (rough estimate)
refractive index 
1.5770 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
10.75±0.20(Predicted)
form 
solid
Appearance
Light yellow to yellow Solid
CAS DataBase Reference
3676-85-5(CAS DataBase Reference)
NIST Chemistry Reference
4-Aminophthalimide(3676-85-5)
EPA Substance Registry System
1H-Isoindole-1,3(2H)-dione, 5-amino- (3676-85-5)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-43-36-25
Safety Statements 
24/25-45-36/37-26
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29251900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS000148
Product name
5-Amino-1H-isoindole-1,3(2H)-dione
Purity
AldrichCPR
Packaging
250mg
Price
$73.1
Updated
2025/07/31
TCI Chemical
Product number
A0966
Product name
4-Aminophthalimide
Purity
>98.0%(GC)
Packaging
5g
Price
$73
Updated
2025/07/31
TCI Chemical
Product number
A0966
Product name
4-Aminophthalimide
Purity
>98.0%(GC)
Packaging
25g
Price
$216
Updated
2025/07/31
TRC
Product number
A619070
Product name
4-Aminophthalimide
Packaging
1g
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA71627
Product name
4-Aminophthalimide
Packaging
5G
Price
$45
Updated
2021/12/16
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4-Aminophthalimide Chemical Properties,Usage,Production

Chemical Properties

YELLOW-BROWN POWDER

Uses

4-Aminophthalimide is used in research as a fluorescent labeling compound.

Synthesis

89-40-7

3676-85-5

General procedure for the synthesis of 4-amino phthalimide from 4-nitrophthalimide: 4-nitrophthalimide (LOOGR) was placed in a hydrogenation reactor and dissolved in 600 mL of dimethylformamide (DMF). Nickel Nguyenay catalyst (20 g, wet weight) was added to this solution and the hydrogenation reaction was initiated at 20-30 °C and 20-40 psi hydrogen pressure. After the exothermic phenomenon of the reaction was over, the hydrogen pressure was increased to 40-60 psi and the reaction temperature was raised to 40-50 °C. Upon completion of the hydrogenation reaction, the reaction mixture was filtered while hot to remove the catalyst. Subsequently, dimethylformamide was recovered from the filtrate by distillation under reduced pressure at 60-80 °C. To the residue, 500 mL of water was added and stirred for 20-30 minutes. The product was separated by filtration and dried at 60-70 °C to give 4-amino phthalimide as a yellow crystalline solid (82 g, 97% yield). Melting point: 293-295°C.

References

[1] Patent: WO2004/43919, 2004, A1. Location in patent: Page 8
[2] Patent: US2011/77394, 2011, A1. Location in patent: Page/Page column 15
[3] Patent: WO2004/43919, 2004, A1. Location in patent: Page 9
[4] ChemCatChem, 2017, vol. 9, # 6, p. 1128 - 1134
[5] Patent: CN104447496, 2017, B. Location in patent: Paragraph 0067; 0070; 0071

4-Aminophthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Aminophthalimide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Aminophthalimide 3676-85-5
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2025-03-11
Asia Chem I and E (Jiangsu) Co Ltd
Product
4-Aminophthalimide 3676-85-5
Price
US $209.30/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.00%HPLC
Supply Ability
4tons/month
Release date
2021-09-24
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Aminophthalimide 3676-85-5
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-06

3676-85-5, 4-AminophthalimideRelated Search:

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