Z-FA-FMK

Product Name: Z-FA-FMK
CAS No.: 105637-38-5
Chemical Name: Z-FA-FMK
Synonyms: Z-FA-FMK;Z-PHE-ALA-FMK;Z-PHE-ALA-CH2F;(S,S)-Z-FA-FMK;CATHEPSIN B, INHIBITOR;Z-FA-FLUOROMETHYLKETONE;CATHEPSIN B, INHIBITOR I;Z-PHE-ALA-FLUOROMETHYLKETONE;CASPASE INHIBITOR, NEGATIVE CONTROL;Z-FA-FMK, Cysteine protease inhibitor
CBNumber: CB9749490
Molecular Formula: C21H23FN2O4
Formula Weight: 386.42
MOL File: 105637-38-5.mol

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Z-FA-FMK Property

Melting point:: 125 - 127°C
Boiling point:: 630.5±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO or DMF: 20 mM
form: powder
pka: 11.07±0.46(Predicted)
color: white to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C1480
Product name: Z-Phe-Ala fluoromethyl ketone
Purity: ≥90% (TLC), powder
Packaging: 3mg
Price: $297
Updated: 2025/07/31

ApexBio Technology

Product number: A8170
Product name: Z-FA-FMK
Packaging: 10mM(in 1mL DMSO)
Price: $250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000079
Product name: Z-FA-FMK
Purity: 95.00%
Packaging: 1MG
Price: $257.25
Updated: 2021/12/16

ApexBio Technology

Product number: A8170
Product name: Z-FA-FMK
Packaging: 1unit
Price: $28
Updated: 2021/12/16

ApexBio Technology

Product number: A8170
Product name: Z-FA-FMK
Packaging: 1mg
Price: $60
Updated: 2021/12/16

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Z-FA-FMK Chemical Properties,Usage,Production

Uses

Cell permeable negative control for FMK-labelled caspase inhibitors. Also an irreversible inhibitor of cathepsins B, L, and S

Uses

Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.

Biological Activity

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor K-light-chain-enhancer of activated B cells (NF-KB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

Z-FA-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-FA-FMK Suppliers

China 66 Germany 1 Switzerland 2 United Kingdom 1 United States 13 Global 83

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

Alexis Corporation

Tel: --
Fax: --
Email: alexis-ch@alexis-corp.ch
Country: Switzerland
ProdList: 3599
Advantage: 74

105637-38-5, Z-FA-FMKRelated Search:

Z-DEVD-FMK Z-Vad-fmk, non-methylated Z-VAD-FMK BIOTIN-FA-FMK,BIOTIN-PHE-ALA-FLUOROMETHYLKETONE Caspase FMK Negative Control, Z-FA-FMK Z-FA-FMK Z-PHE-PHE-FLUOROMETHYLKETONE Z-PHE-DL-ALA-FLUOROMETHYLKETONE

NEGATIVE CONTROL INHIBITOR FOR ICE PROTEASES

Z-FA-FLUOROMETHYLKETONE

Z-FA-FMK

Z-PHE-ALA-CH2F

Z-PHE-ALA-FLUOROMETHYLKETONE

Z-PHE-ALA-FMK

CASPASE INHIBITOR, NEGATIVE CONTROL

CATHEPSIN B, INHIBITOR

CATHEPSIN B, INHIBITOR I

Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

Carbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-1-methyl-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester

(S)-2-(Cbz-amino)-N-[(S)-4-fluoro-3-oxo-2-butyl]-3-phenylpropanamide

Z-FA-FMK, Cysteine protease inhibitor

(S,S)-Z-FA-FMK

105637-38-5

C21H23N2O4F

Caspase/Related Products

Inhibitor