Bromotrimethylsilane
Uses- Product Name
- Bromotrimethylsilane
- CAS No.
- 2857-97-8
- Chemical Name
- Bromotrimethylsilane
- Synonyms
- TMSBR;TRIMETHYLSILYL BROMIDE;TRIMETHYLBROMOSILANE;TMBS;(CH3)3SiBr;Silane, bromotrimethyl-;CT2928;TMS bromide;BromotrimethyL;Co-Formula CFS-978
- CBNumber
- CB9749809
- Molecular Formula
- C3H9BrSi
- Formula Weight
- 153.09
- MOL File
- 2857-97-8.mol
Bromotrimethylsilane Property
- Melting point:
- -43 °C
- Boiling point:
- 79 °C(lit.)
- Density
- 1.16 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.424(lit.)
- Flash point:
- 90 °F
- storage temp.
- Store below +30°C.
- solubility
- DECOMPOSES
- form
- Liquid
- Specific Gravity
- 1.1725
- color
- Clear colorless to yellow
- Water Solubility
- DECOMPOSES
- Sensitive
- Moisture Sensitive
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 1731135
- Stability:
- Stable. Flammable. Incompatible with strong acids, strong oxidizing agents. May decompose on exposure to water or moist air.
- CAS DataBase Reference
- 2857-97-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Bromotrimethylsilane(2857-97-8)
- EPA Substance Registry System
- Silane, bromotrimethyl- (2857-97-8)
Safety
- Hazard Codes
- C
- Risk Statements
- 10-34-29-14
- Safety Statements
- 16-26-36/37/39-45-8
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 3
- F
- 10-21
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29310095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.14324
- Product name
- Bromotrimethylsilane
- Purity
- for synthesis
- Packaging
- 10ml
- Price
- $88.7
- Updated
- 2024/03/01
- Product number
- 194409
- Product name
- Bromotrimethylsilane
- Purity
- 97%
- Packaging
- 5g
- Price
- $41.5
- Updated
- 2024/03/01
- Product number
- 8.14324
- Product name
- Bromotrimethylsilane
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $290
- Updated
- 2024/03/01
- Product number
- 194409
- Product name
- Bromotrimethylsilane
- Purity
- 97%
- Packaging
- 25g
- Price
- $103
- Updated
- 2024/03/01
- Product number
- B1087
- Product name
- Bromotrimethylsilane
- Purity
- >95.0%(GC)
- Packaging
- 5mL
- Price
- $32
- Updated
- 2024/03/01
Bromotrimethylsilane Chemical Properties,Usage,Production
Uses
Bromotrimethylsilane can protect or deprotect functional groups selectively, act as silane blocking agent, which is widely used in the syntheses of drugs.
Chemical Properties
Clear yellow liquid
Physical properties
bp 79°C; d 1.188 g cm?3; n20 D 1.4240; fp 32°C.
Uses
Powerful silylating agent
Uses
Adefovir intermediate
Uses
Bromotrimethylsilane is a mild and selective reagent for cleavage of lactones, epoxides,
acetals, phosphonate esters and certain ethers; effective reagent
for formation of silyl enol ethers; can function as brominating
agent.
Amines react with TMS-Br to form
isolable adducts, which react readily with ketones to form enamines
under mild conditions (eq 15).
Preparation
although many methods are reported, only a few are provided here: chlorotrimethylsilane undergoes halogen exchange with either magnesium bromide in Et2O or sodium bromide in MeCN, which allows in situ reagent formation (eq 1); alternatively, hexamethyldisilane reacts with bromine in benzene solution or neat, to afford only TMS-Br with no byproducts (eq 2).4 TMS-Br may also be generated by reaction of hexamethyldisiloxane and aluminum bromide (eq 3).However, it should be noted that the reactivity of in situ generated reagent appears to depend upon the method of preparation.
General Description
Bromotrimethylsilane is used with Cl3 to catalyze the direct allylation of a variety of alcohols with allyltrimethylsilane.
Purification Methods
Purify it by repeated fractional distillation and store it in sealed ampoules in the dark. [McCusker & Reilly J Am Chem Soc 75 1583 1953.] Also fractionate it through a 15-plate column (0.8 x 32cm packed with 1/16in single turn helices of Pt-Ir wire). [Gilliam et al. J Am Chem Soc 68 1161 1946, Pray et al. J Am Chem Soc 70 433 1948, Beilstein 4 IV 4008.]
Bromotrimethylsilane Preparation Products And Raw materials
Raw materials
Preparation Products
Bromotrimethylsilane Suppliers
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View Lastest Price from Bromotrimethylsilane manufacturers
- Product
- Bromotrimethylsilane 2857-97-8
- Price
- US $1000.00-700.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-14
- Product
- Trimethylbromosilane 2857-97-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 20 tons
- Release date
- 2024-04-28
- Product
- Bromotrimethylsilane 2857-97-8
- Price
- US $20548.00-20000.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 7000ton
- Release date
- 2023-09-15