ChemicalBook > CAS DataBase List > DC-CHOL

DC-CHOL

Product Name: DC-CHOL
CAS No.: 166023-21-8
Chemical Name: DC-CHOL
Synonyms: DC-CHO;DC-CHOL;DC-CHOLESTEROL;DC-Cholesterol.HCl;DC-Chol (hydrochloride);DC-cholesterol hydrochloride;Cholesteryl 3β-N-(dimethylaminoethyl)carbamate;cholesteryl 3B-(N-(dimethylaminoethyl)*carbamate);3β-[n-(dimethylaminoethane) carbamoyl] cholesterol;Cholesteryl 3β-N-(di-methyl-amino-ethyl)-carbamate
CBNumber: CB9751215
Molecular Formula: C32H56N2O2.ClH
Formula Weight: 537.26
MOL File: 166023-21-8.mol

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DC-CHOL Property

storage temp.: -20°C
solubility: DMSO: > 5mg/mL; Methanol: > 10 mg/mL
form: A crystalline solid
color: White to light yellow
InChIKey: ISXSJGHXHUZXNF-JSYXOEMKNA-N
SMILES: C[C@]12CC[C@@H](CC1=CC[C@@]1([H])[C@]3([H])CC[C@@]([H])([C@]3(CC[C@@]12[H])C)[C@H](C)CCCC(C)C)OC(=O)NCCN(C)C.Cl |&1:1,4,9,11,15,17,20,23,r|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2832
Product name: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride
Purity: ≥95%
Packaging: 25mg
Price: $126
Updated: 2025/07/31

Sigma-Aldrich

Product number: C2832
Product name: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride
Purity: ≥95%
Packaging: 100mg
Price: $411
Updated: 2025/07/31

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 50mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 250mg
Price: $486
Updated: 2024/03/01

Cayman Chemical

Product number: 16943
Product name: DC-Chol (hydrochloride)
Packaging: 25mg
Price: $63
Updated: 2024/03/01

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DC-CHOL Chemical Properties,Usage,Production

Description

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE , has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.

Uses

This cationic cholesterol derivative forms liposomes with L-α-phosphatidylethanolamine, dioleoyl, that efficiently transfect mammalian cell lines.

Uses

DC-Cholesterol HCl is suitable:

for the preparation of ultrasound cationic microbubbles
to prepare liposomes
for the preparation of L-glutathione (GSH), loaded proliposomes

General Description

DC-Cholesterol HCl is a sterol-based transfection reagent.

Biochem/physiol Actions

DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).

storage

Store at -20°C

References

[1] TATJANA MICHEL. Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.[J]. Molecular Therapy. Nucleic Acids, 2017, 8: 459-468. DOI: 10.1016/j.omtn.2017.07.013
[2] JIE GAO . Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing[J]. Biomaterials, 2010, 31 9: Pages 2655-2664. DOI: 10.1016/j.biomaterials.2009.11.112
[3] RAN ZHANG. Codelivery of paclitaxel and small interfering RNA by octadecyl quaternized carboxymethyl chitosan-modified cationic liposome for combined cancer therapy.[J]. Journal of Biomaterials Applications, 2015, 30 3: 351-360. DOI: 10.1177/0885328215579297
[4] YING MEN. The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals.[J]. International Journal of Nanomedicine, 2011: 3125-3137. DOI: 10.2147/ijn.s24847
[5] X XING. Safety studies of the intraperitoneal injection of E1A–liposome complex in mice[J]. Gene Therapy, 1997, 4 3: 238-243. DOI: 10.1038/sj.gt.3300376

DC-CHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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DC-CHOL Suppliers

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View Lastest Price from DC-CHOL manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DC-Chol
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-30

166023-21-8, DC-CHOLRelated Search:

Oleic acid Glycerol Egg phospholipids D(+)-Trehalose dihydrate Soy bean phospholipid(For Injection)

cholesteryl 3B-(N-(dimethylaminoethyl)*carbamate)

3β-[n-(dimethylaminoethane) carbamoyl] cholesterol

CHOLESTERYL N-[DIMETHYL-AMINOETHYL]CARBAMATE HYDROCHLORIDE

DC-CHOL

DC-CHOLESTEROL

DC-Chol (hydrochloride)

DC-CHO

DC-Cholesterol.HCl

cholesteryl 3beta-N-(dimethylaminomethyl)carbamate HCl

3β-[N-(Dimethylaminoethane)carbamoyl]cholesterol, DC-Chol

O-[(N,N-Dimethylaminoethyl)-carbamoyl]cholesterol hydrochloride

cholesteryl 3β-n-(di methyl amino ethyl)carbamate hydrochloride

3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol

Cholesteryl 3β-N-(di-methyl-amino-ethyl)-carbamate

Cholesteryl 3beta-N-(di-methyl-amino-ethyl)-carbamate hydrochloride

Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (2-(dimethylamino)ethyl)carbamate hydrochloride

Cholesteryl 3β-N-(di-methyl-amino-ethyl)-carbamate hydrochloride

DC-cholesterol hydrochloride

Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride|||DC-Chol (hydrochloride)|||DC-Cholesterol hydrochloride|||?Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

Cholest-5-en-3-ol (3β)-, 3-[N-[2-(dimethylamino)ethyl]carbamate], hydrochloride (1:1)

166023-21-8

C32H56N2O2HCl

C32H57ClN2O2

C32H57N2O2Cl

C32H56N2O2

C29H51ClN2O2

BioChemical

Transfection & Transformation

Molecular Biology

Cloning and Expression