3-HYDROXY-5-METHOXYBENZOIC ACID
- Product Name
- 3-HYDROXY-5-METHOXYBENZOIC ACID
- CAS No.
- 19520-75-3
- Chemical Name
- 3-HYDROXY-5-METHOXYBENZOIC ACID
- Synonyms
- 19520-75-3;AKOS 214-12;3-HYDROXY-5-METHOXYBENZOIC ACID;Benzoic acid, 3-hydroxy-5-methoxy-
- CBNumber
- CB9777990
- Molecular Formula
- C8H8O4
- Formula Weight
- 168.15
- MOL File
- 19520-75-3.mol
3-HYDROXY-5-METHOXYBENZOIC ACID Property
- Melting point:
- 202-203 °C
- Boiling point:
- 394.7±27.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.96±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H855050
- Product name
- 3-Hydroxy-5-methoxybenzoicacid
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CHM0389191
- Product name
- 3-HYDROXY-5-METHOXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.41
- Updated
- 2021/12/16
- Product number
- CD12100136
- Product name
- 3-Hydroxy-5-methoxybenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $767
- Updated
- 2021/12/16
3-HYDROXY-5-METHOXYBENZOIC ACID Chemical Properties,Usage,Production
Definition
ChEBI: 3-hydroxy-5-methoxybenzoic acid is a methoxybenzoic acid.
Synthesis
19520-74-2
19520-75-3
GENERAL METHOD: Methyl 3-hydroxy-5-methoxybenzoate (4.5 g, 16.7 mmol) was dissolved in methanol (30 mL) and 1M sodium hydroxide solution (60 mL, 60 mmol) was added under nitrogen protection. The reaction mixture was stirred at 45 °C for 1-2 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was acidified with 1 M hydrochloric acid (50 mL) and subsequently extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with distilled water (2 × 30 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 3-hydroxy-5-methoxybenzoic acid (5a) as an off-white solid (4.02 g, 94% yield) with a melting point of 196-198 °C.1H NMR (400 MHz, acetone-d6) δ (ppm): 7.42-7.33 (5H, m, benzyl Ph), 7.21 (1H, dd, J = 2.4,1.2 Hz. H-2), 7.11 (1H, dd, J = 2.4,1.2Hz, H-6), 6.68 (1H, t, J = 2.4Hz, H-4), 5.07 (2H, s, benzyl CH2). The obtained 1H NMR spectrum is in agreement with data reported in the literature [38].
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 415 - 422
[2] Journal of the American Chemical Society, 2005, vol. 127, # 6, p. 1737 - 1743
[3] Acta Phytochimica, 1939, vol. 11, p. 167,179
[4] Acta Phytochimica, 1939, vol. 11, p. 167,179
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