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COH34

Product Name: COH34
CAS No.: 906439-72-3
Chemical Name: COH34
Synonyms: COH34;COH34, 10 mM in DMSO;1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol;1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol , COH34;1-({[(4-methylphenyl)sulfanyl]imino}methyl)naphthalen-2-ol;1-Naphthalenecarboxaldehyde, 2-hydroxy-, S-(4-methylphenyl)thiooxime
CBNumber: CB98054354
Molecular Formula: C18H15NOS
Formula Weight: 293.38
MOL File: 906439-72-3.mol

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COH34 Property

Boiling point:: 495.5±55.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
pka: 8.07±0.50(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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COH34 Chemical Properties,Usage,Production

Uses

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].

in vivo

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models^[1].

References

[1] Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. DOI:10.1126/sciadv.aav4340

COH34 Preparation Products And Raw materials

Raw materials

Preparation Products

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906439-72-3, COH34Related Search:

COH34

1-Naphthalenecarboxaldehyde, 2-hydroxy-, S-(4-methylphenyl)thiooxime

1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol

1-({[(4-methylphenyl)sulfanyl]imino}methyl)naphthalen-2-ol

COH34, 10 mM in DMSO

1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol , COH34

906439-72-3