ChemicalBook > CAS DataBase List > COH34
COH34
- Product Name
- COH34
- CAS No.
- 906439-72-3
- Chemical Name
- COH34
- Synonyms
- COH34;COH34, 10 mM in DMSO;1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol;1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol , COH34;1-({[(4-methylphenyl)sulfanyl]imino}methyl)naphthalen-2-ol;1-Naphthalenecarboxaldehyde, 2-hydroxy-, S-(4-methylphenyl)thiooxime
- CBNumber
- CB98054354
- Molecular Formula
- C18H15NOS
- Formula Weight
- 293.38
- MOL File
- 906439-72-3.mol
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COH34 Property
- Boiling point:
- 495.5±55.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- pka
- 8.07±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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COH34 Chemical Properties,Usage,Production
Uses
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
in vivo
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
References
[1] Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340. DOI:10.1126/sciadv.aav4340
COH34 Preparation Products And Raw materials
Raw materials
Preparation Products
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COH34 Suppliers
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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- United States
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- +1-781-999-5354;
- support@targetmol.com
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- United States
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