9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester

Product Name: 9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
CAS No.: 182261-83-2
Chemical Name: 9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
Synonyms: Clausine E, 10 mM in DMSO;9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
CBNumber: CB98081756
Molecular Formula: C14H11NO3
Formula Weight: 241.24
MOL File: 182261-83-2.mol

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9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Property

Melting point:: 215-216.5 °C
Boiling point:: 512.7±30.0 °C(Predicted)
Density: 1.400±0.06 g/cm3(Predicted)
pka: 9.34±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN91823
Product name: ClausineE
Purity: ≥98%
Packaging: 5mg
Price: $318
Updated: 2021/12/16

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9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Chemical Properties,Usage,Production

Uses

Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

Definition

ChEBI: Clausine E is a member of carbazoles. It has a role as a metabolite.

References

[1] Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. DOI:10.1002/jmr.2800
[2] Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. DOI:10.19540/j.cnki.cjcmm.20210429.203
[3] Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619. DOI:10.1016/j.bmc.2007.05.033

9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Preparation Products And Raw materials

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9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester

Clausine E, 10 mM in DMSO

182261-83-2